STUDY OF EFFICACY, SAFETY AND DOSAGE ON CEFPODOXIME PROXETIL IN PEDIATRIC INFECTIONS

Cefpodoxime proxetil (CS-807, CPDX-PR), a new cephalosporin antibiotic, was investigated for its usefulness in pediatrics. 1. The total number of patients treated were 21 with their ages ranging from 3 months to 9 years and 1 month, consisting of 5 male and 16 female infants. 2. Single dosages of th...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1989/07/25, Vol.42(7), pp.1498-1504
Main Authors: HIROSAWA, HIROSHI, ISHIKAWA, YASUKO, TAKAHASHI, SHINTARO, MATSUDA, HIROO, ICHIHASHI, HARUO
Format: Article
Language:Japanese
Subjects:
Administration, Oral
Bacteria - drug effects
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Cefpodoxime Proxetil
Ceftizoxime - administration & dosage
Ceftizoxime - analogs & derivatives
Ceftizoxime - pharmacology
Ceftizoxime - therapeutic use
Child
Child, Preschool
Drug Evaluation
Drug Resistance, Microbial
Female
Humans
Infant
Male
Pharyngitis - drug therapy
Pharyngitis - microbiology
Tonsillitis - drug therapy
Tonsillitis - microbiology
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Summary:Cefpodoxime proxetil (CS-807, CPDX-PR), a new cephalosporin antibiotic, was investigated for its usefulness in pediatrics. 1. The total number of patients treated were 21 with their ages ranging from 3 months to 9 years and 1 month, consisting of 5 male and 16 female infants. 2. Single dosages of the drug ranged between 4.4mg and 5.8mg/kg with oral administration for 3 times daily in fasting. A total aggregated dosage was between 46.4mg/kg and 200.0mg/kg. The length of administration was 3 to 12 days. 3. The breakdown of symptoms were 9 cases of acute pharyngitis, 5 cases of acute tonsillitis, 3 cases of acute bronchitis, and 1 case each of impetigo +purulent rhinitis, cervical lymphadenitis, scarlet fever, and urinary tract infection. 4. The clinical efficacy rate was 100% with 18 excellent responses and 3 good responses. 5. The bacteriological efficacy rate was 90.9% in eradication rate, based on results on 17 strains of suspected causative microorganism among which 10 strains were eradicated, 1 strain was decreased, and 6 strains were unknown. 6. There was no side effect during the treatment and after the discontinuation, while, in clinical laboratory tests, GOT and GPT were elevated in 1 case which was judged as abnormal. No patient refused the drug. CPDX-PR was considered to be very useful drug because of its excellent efficacy and safety in pediatrics in treating infectious diseases.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.42.1498