Effects of Ammonia on the Gastric Mucosal Barrier in Rats and Dogs

We examined the effect of ammonia on the gastric mucosal barrier by measuring the changes in transmucosal fluxes of H+, Na+ and K+. In rats, ammonia at concentrations of 0.1 to 0.5% increased the H+ loss from the lumen and 0.2 to 0.5% concentrations of ammonia increased both Na+ and K+ influxes into...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1989, Vol.51(1), pp.143-145
Main Authors: SEIKI, Masao, MURAKAMI, Motonobu, YOO, Jung Keun, TERANUMA, Sanae, SAITA, Hiroshi, INADA, Masami, KITA, Toru, MIYAKE, Takeo
Format: Article
Language:English
Subjects:
Ammonia - pharmacology
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Dogs
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
General aspects
Hydrogen - metabolism
Male
Medical sciences
Potassium - metabolism
Rats
Rats, Inbred Strains
Sodium - metabolism
Species Specificity
Toxicology
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Summary:We examined the effect of ammonia on the gastric mucosal barrier by measuring the changes in transmucosal fluxes of H+, Na+ and K+. In rats, ammonia at concentrations of 0.1 to 0.5% increased the H+ loss from the lumen and 0.2 to 0.5% concentrations of ammonia increased both Na+ and K+ influxes into the lumen. In dogs, in an exactly similar manner to rats, ammonia at concentrations of 0.1 to 0.5% increased H+ loss, and ammonia at concentration of 0.5% increased both Na+ and K+ influxes into the lumen. These results suggest that ammonia breaks the gastric mucosal barrier.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.51.143