Development of a CCD array imaging system for measurement of dose distributions in doped agarose gels

An imaging system for agarose gel sections has been investigated for applications in rapid two-dimensional radiation dosimetry. The imaging system, with white light illumination and CCD camera detection, was designed for measurement of the radiation-induced optical density changes in iron- and xylen...

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Bibliographic Details
Published in:Medical physics (Lancaster) 1997-09, Vol.24 (9), p.1521-1525
Main Authors: Tarte, B. J., Jardine, P. A., van Doorn, T., Nitschke, K. N., Poulsen, M. G.
Format: Article
Language:English
Subjects:
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Biophysical Phenomena
Biophysics
Cameras
CCD image sensors
Charge coupled devices
Doping
dosimetry
Effects of ionizing radiation on biological systems
Evaluation Studies as Topic
Gels
Gels and sols
Humans
Illumination
Image detection systems
Imaging detectors and sensors
Ionization chambers
Lasers
Medical imaging
Optics and Photonics - instrumentation
Photography - instrumentation
radiation therapy
Radiation therapy equipment
Radiometry - instrumentation
Radiometry - methods
Radiometry - statistics & numerical data
Radiotherapy Planning, Computer-Assisted - instrumentation
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy Planning, Computer-Assisted - statistics & numerical data
Sepharose
Therapeutics
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Summary:An imaging system for agarose gel sections has been investigated for applications in rapid two-dimensional radiation dosimetry. The imaging system, with white light illumination and CCD camera detection, was designed for measurement of the radiation-induced optical density changes in iron- and xylenol orange dye-doped agarose gels. The performance of the imaging system was compared with that of a laser scanning system for the gels and with the accepted dosimetry standard, the ionization chamber. In measurement of beam profiles of two therapeutic radiation fields, relative dose values from the CCD camera imaging system were on average within 3% (ranging from 0.005% to 7.5%) of values recorded with a parallel plate ionization chamber. In comparison with the laser scanner, the CCD camera imaging system provided comparable spatial resolution and an increased rate of data acquisition, although a consistently reduced signal to noise ratio was observed. Suggestions for improving the camera imaging technique include noise reduction through camera cooling and further frame averaging.
ISSN:0094-2405
2473-4209
DOI:10.1118/1.598041