Antiepileptic Effects of 20-Hydroxyecdysone on Convulsive Seizures in Spontaneously Epileptic Rats

We examined the effect of 20-hydroxyecdysone (20-HE), a neurosteroid found in insects that is involved in their developmental process, on both tonic convulsion and absence-like seizure in spontaneously epileptic rat (SER). When 20-HE was given orally to SER at 25 200 mg/kg, significant decreases of...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1997, Vol.74(4), pp.331-335
Main Authors: Hanaya, Ryosuke, Sasa, Masashi, Ishihara, Kumatoshi, Akimitsu, Tomohide, Iida, Koji, Amano, Taku, Serikawa, Tadao, Arita, Kazunori, Kurisu, Kaoru
Format: Article
Language:English
Subjects:
20-Hydroxyecdysone
Administration, Oral
Animals
Anticonvulsants - antagonists & inhibitors
Anticonvulsants - therapeutic use
Antiepileptic effect
Bicuculline - pharmacology
Convulsants - pharmacology
Disease Models, Animal
Ecdysterone - antagonists & inhibitors
Ecdysterone - therapeutic use
Epilepsy - drug therapy
Female
Male
Rats
Rats, Inbred WKY
Rats, Sprague-Dawley
Receptors, GABA-A - drug effects
Receptors, GABA-A - metabolism
Spontaneously epileptic rat (SER)
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Summary:We examined the effect of 20-hydroxyecdysone (20-HE), a neurosteroid found in insects that is involved in their developmental process, on both tonic convulsion and absence-like seizure in spontaneously epileptic rat (SER). When 20-HE was given orally to SER at 25 200 mg/kg, significant decreases of the tonic convulsion were observed with 100 and 200 mg/kg. Pretreatment of the animal with bicuculline (1 mg/kg, i.p.)antagonized the inhibitory effects of 20-HE. However, absence-like seizures were not affected by 20-HE. These findings indicate that 20-HE produces antiepileptic effects on tonic convulsion by acting on the modulatory site of GABAA receptors.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.74.331