The control of calcium influx by cytoplasmic calcium in mammalian heart muscle

The role of Ca2+ in the initiation and maintenance of contraction has been extensively studies. Many of these studies have focused on how Ca2+ influx and efflux affect cytoplasmic Ca2+ (Cai) and, therefore, contraction in cardiac muscle. However, it has recently become apparent that Cai itself may p...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1989-09, Vol.89 (2), p.109-113
Main Authors: Kirby, M S, Orchard, C, Boyett, M R
Format: Article
Language:English
Subjects:
Animals
Biological Transport
calcium
Calcium - metabolism
Calcium Channels - metabolism
cardiac muscle
Carrier Proteins - metabolism
Cytoplasm - metabolism
Dogs
Guinea Pigs
Ion Exchange
Membrane Potentials
Myocardial Contraction - physiology
Myocardium - metabolism
Rabbits
Rats
Sodium - metabolism
Sodium-Calcium Exchanger
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Summary:The role of Ca2+ in the initiation and maintenance of contraction has been extensively studies. Many of these studies have focused on how Ca2+ influx and efflux affect cytoplasmic Ca2+ (Cai) and, therefore, contraction in cardiac muscle. However, it has recently become apparent that Cai itself may play a major role in the control of Ca2+ influx and efflux from cardiac muscle. Here we review current ideas on the mechanisms underlying Ca2+ homeostasis in cardiac muscle, with specific attention to how Cai may control Ca2+ influx, both under normal and pathological conditions.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00220761