Protein phosphorylation and compartments of cyclic AMP in the control of cardiac contraction

The roles of cyclic AMP, cyclic AMP-dependent protein kinase and the phosphorylation of specific proteins in the regulation of cardiac contractility are briefly reviewed. Criteria for determining whether changes in cyclic AMP and protein phosphorylation are involved in a physiological response are d...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1989-09, Vol.89 (2), p.175-179
Main Authors: Murray, K J, Reeves, M L, England, P J
Format: Article
Language:English
Subjects:
Animals
Calcium Channels - metabolism
Calcium-Binding Proteins - metabolism
cardiac muscle
Carrier Proteins
cyclic AMP
Cyclic AMP - physiology
Muscle Proteins - metabolism
Myocardial Contraction - physiology
Myocardium - metabolism
Phosphorylation
Protein Kinases - metabolism
Proteins - metabolism
Troponin - metabolism
Troponin I
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Summary:The roles of cyclic AMP, cyclic AMP-dependent protein kinase and the phosphorylation of specific proteins in the regulation of cardiac contractility are briefly reviewed. Criteria for determining whether changes in cyclic AMP and protein phosphorylation are involved in a physiological response are discussed. Although cyclic AMP-dependent phosphorylation of the voltage-operated Ca2+ channel, phospholamban, troponin-I and C-protein have all been implicated in the response of the heart to inotropic agents which elevate cyclic AMP, none of these phosphorylations satisfy all of the criteria completely. Evidence is presented that there are compartments of cyclic AMP in heart which are coupled to different functional responses.
ISSN:0300-8177
1573-4919
DOI:10.1007/bf00220772