Plasma somatostatin and cholecystokinin levels in sick preterm infants during their first six weeks of life

The present study reports the levels of plasma somatostatin and cholecystokinin in 19 preterm infants with asphyxia [n=10, GA (median; range) 26; 23–30 weeks] and respiratory distress syndrome (n= 14, GA 27; 23–29 weeks) compared with preterm infants without any of these conditions (reference group,...

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Bibliographic Details
Published in:Acta Paediatrica 1997-08, Vol.86 (8), p.847-850
Main Authors: Törnhage, C-J, Serenius, F, Uvnäs-Moberg, K, Lindberg, T
Format: Article
Language:English
Subjects:
Asphyxia
Asphyxia Neonatorum - blood
Asphyxia Neonatorum - therapy
Biological and medical sciences
cholecystokinin
Cholecystokinin - blood
Delivery. Postpartum. Lactation
Disorders
Female
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - blood
Infant, Premature, Diseases - therapy
Jaundice, Neonatal - blood
Jaundice, Neonatal - therapy
Male
Medical sciences
Phototherapy
preterm infant
Radioimmunoassay
respiratory distress syndrome
Respiratory Distress Syndrome, Newborn - blood
Respiratory Distress Syndrome, Newborn - therapy
somatostatin
Somatostatin - blood
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Summary:The present study reports the levels of plasma somatostatin and cholecystokinin in 19 preterm infants with asphyxia [n=10, GA (median; range) 26; 23–30 weeks] and respiratory distress syndrome (n= 14, GA 27; 23–29 weeks) compared with preterm infants without any of these conditions (reference group, n= 59, GA 33; 25–36 weeks). In the reference group 37 infants received phototherapy and their peptide levels were compared with those not receiving phototherapy (n= 22). Plasma somatostatin and cholecystokinin were analysed by specific radioimmunoassays on day 1, day 3–4 and at 6 weeks of life. Plasma somatostatin levels, but not cholecystokinin levels, of reference infants were inversely related to gestational age on day 1 and day 3–4. Asphyxiated infants and infants with respiratory distress syndrome had significantly higher somatostatin levels than reference infants on day 1 and day 3–4. These differences disappeared when the levels were adjusted for gestational age. Plasma cholecystokinin levels were not influenced by respiratory distress syndrome and asphyxia. Phototherapy did not affect plasma somatostatin and cholecystokinin levels.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.1997.tb08609.x