Grey matter correlates of syndromes in schizophrenia. A semi-automated analysis of structural magnetic resonance images

Symptoms in schizophrenia cluster into syndromes, each of which may be associated with a particular pattern of cerebral blood flow. We sought to investigate whether these syndromes are also related to neuroanatomical changes. A semi-automated method was used to examine structural magnetic resonance...

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Bibliographic Details
Published in:British journal of psychiatry 1997-05, Vol.170 (5), p.406-410
Main Authors: Chua, SE, Wright, IC, Poline, JB, Liddle, PF, Murray, RM, Frackowiak, RS, Friston, KJ, McGuire, PK
Format: Article
Language:English
Subjects:
Adult
Anniversaries
Automation
Brain Diseases - diagnostic imaging
Brain Diseases - pathology
Female
Humans
Hypotheses
Magnetic Resonance Imaging
Male
Medical imaging
Neuroimaging
Psychiatry
Psychomotor Disorders - psychology
Psychopathology
Regions
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - pathology
Syndrome
Tomography, Emission-Computed
Citations: Items that this one cites
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Summary:Symptoms in schizophrenia cluster into syndromes, each of which may be associated with a particular pattern of cerebral blood flow. We sought to investigate whether these syndromes are also related to neuroanatomical changes. A semi-automated method was used to examine structural magnetic resonance images in 12 patients with schizophrenia. The relationship between the relative regional grey matter volume and ratings of the syndromes of psychomotor poverty, disorganisation and reality distortion was investigated. There was a significant negative correlation between psychomotor poverty score and the relative volume of the left ventro-medial prefrontal grey matter, and a significant positive correlation between disorganisation and the relative volumes of the hippocampus, and the parahippocampal/fusiform gyrus bilaterally. The correlation between psychomotor poverty and left prefrontal grey matter volume resembles that previously seen with prefrontal blood flow in the same patient, suggesting that this functional abnormality is related to an underlying anatomical change.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.170.5.406