Correlation Between Gadolinium-Diethylenetriaminepentaacetic Acid Contrast Enhancement and Thallium-201 Chloride Uptake in Pediatric Brainstem Glioma

We previously showed that thallium-201 (201Tl) chloride is accumulated in over 75% of brain tumors, including brainstem gliomas. The imaging of 201Tl with single photon emission computed tomography (SPECT) may require an abnormal increase in permeability of tumor vessels to allow penetration of the...

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Bibliographic Details
Published in:Journal of child neurology 1997-09, Vol.12 (6), p.341-348
Main Authors: Maria, Bernard L., Drane, Walter B., Quisling, Ronald J., Hoang, Karin B. N.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood-Brain Barrier
Brain Neoplasms - diagnostic imaging
Brain Stem - diagnostic imaging
Brain Stem - physiopathology
Capillary Permeability
Child
Child, Preschool
Contrast Media - pharmacokinetics
Disease Progression
Gadolinium DTPA
Glioma - diagnostic imaging
Humans
Longitudinal Studies
Magnetic Resonance Imaging - standards
Neoplasm, Residual - diagnostic imaging
Prognosis
Retrospective Studies
Thallium Radioisotopes - pharmacokinetics
Tomography, Emission-Computed, Single-Photon - methods
Tomography, Emission-Computed, Single-Photon - standards
Treatment Outcome
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Summary:We previously showed that thallium-201 (201Tl) chloride is accumulated in over 75% of brain tumors, including brainstem gliomas. The imaging of 201Tl with single photon emission computed tomography (SPECT) may require an abnormal increase in permeability of tumor vessels to allow penetration of the blood-brain barrier. To test this hypothesis, we evaluated the correlation between gadolinium enhancement and the degree of 201T1 uptake on SPECT and the contributions of either gadolinium enhancement or 201Tl uptake to the prognosis in children with brainstem gliomas. Forty-two sets of paired SPECT scans and magnetic resonance imaging (MRI) scans were obtained longitudinally in 13 cases. Altogether, 31 of 42 pairs (74%) of scans showed concordance between the presence of gadolinium enhancement and 201Tl uptake. There were no cases that demonstrated 201Tl uptake but lacked gadolinium enhancement. The results indicate that 201Tl SPECT is of value primarily when brainstem tumors have vessels that are demonstrably permeable to gadolinium, prior to or as a result of radiotherapy. (J Child Neurol 1997; 12:341-348).
ISSN:0883-0738
1708-8283
DOI:10.1177/088307389701200601