Reduced schedule of human antirabies immunization with fuenzalida & Palacios vaccine

The present study evaluates the humoral and cellular immune responses in 35 volunteers submitted to short antirabies vaccination schedules with the Fuenzalida & Palacios vaccine based on the administration of doses on non consecutive days. The volunteers were divided into two groups. The first g...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo 1989, Vol.31 (1), p.23-27
Main Authors: ROBERTO ZANETTI, C, REGINA FAVORETTO, S, SILVA TINO, M, ALBAS, A, G. VALENTINI, E. J, DE C. FEREIRA, O. A
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral - analysis
Antibody Formation
Biological and medical sciences
Human viral diseases
Humans
Immunity, Cellular
Immunization
Immunologic Tests
Infectious diseases
Lymphocyte Activation
Medical sciences
Middle Aged
Rabies Vaccines - administration & dosage
Rabies virus - immunology
Skin Tests
Tropical medicine
Viral diseases
Viral diseases of the nervous system
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Summary:The present study evaluates the humoral and cellular immune responses in 35 volunteers submitted to short antirabies vaccination schedules with the Fuenzalida & Palacios vaccine based on the administration of doses on non consecutive days. The volunteers were divided into two groups. The first group received a total number of five doses given on days 0, 4, 7, 20 and 35. The other group received four doses, the first one being a double dose given on day 0 and than three other single doses on days 7, 20 and 35. The evaluation of humoral immune response was carried out by serum neutralization (SN) and indirect immunofluorescence (IIF) tests, while the cellular immune response was evaluated by lymphoblastic transformation assay (LTA) and skin test (ST). According to our results these reduced schedules elicited early and effective humoral and cellular immune responses to rabies antigen suggesting that new reduced schedules should be extensively studied in order to give the proper bases to the proposition of changes in the current long-term schedule.
ISSN:0036-4665
1678-9946
DOI:10.1590/S0036-46651989000100005