The effects of anesthesia and physical restraint on intra- and extracellular tumor pH, tumor temperature and bioenergetics in murine RIF-1 tumors

The effects of pentobarbital anesthetic and physical restraint have been evaluated in murine RIF-1 tumors in terms of their suitability in providing minimal temporal variations in core and tumor temperatures, intracellular (pHMR) and extracellular (pHF) tumor pH, and tumor bioenergetics. pHF was mea...

Full description

Saved in:
Bibliographic Details
Published in:Magnetic resonance imaging 1997, Vol.15 (7), p.847-855
Main Authors: Jayasundar, Rama, Hall, Laurance D., Bleehen, Norman M.
Format: Article
Language:English
Subjects:
Adjuvants, Anesthesia - pharmacology
Animals
Biological and medical sciences
Energy Metabolism
Fibrosarcoma - metabolism
Fibrosarcoma - physiopathology
Hydrogen-Ion Concentration
Hyperthermia
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Spectroscopy (MRS)
Magnetic Resonance Spectroscopy - methods
Male
Medical sciences
Mice
Mice, Inbred C3H
Miscellaneous. Technology
Neoplasms, Experimental - metabolism
Neoplasms, Experimental - physiopathology
Pentobarbital - pharmacology
Phosphates - metabolism
Phosphocreatine - metabolism
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Restraint, Physical
Temperature
Tumor pH
Tumor temperature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of pentobarbital anesthetic and physical restraint have been evaluated in murine RIF-1 tumors in terms of their suitability in providing minimal temporal variations in core and tumor temperatures, intracellular (pHMR) and extracellular (pHF) tumor pH, and tumor bioenergetics. pHF was measured using a fibreoptic pH probe. The implications of the changes in these parameters on the combined studies of in vivo MRS and hyperthermia have been discussed. The temporal variations of core and tumor temperatures, pHF and pHMR between the anesthetised and restrained mice were statistically significant (p
ISSN:0730-725X
1873-5894
DOI:10.1016/S0730-725X(97)00024-6