Genetic Analysis of Experimentally Induced Lupus in Mice

The DBA/2 and C57BL/6 mouse strains, as well as the BXD RI lines derived from these strains, were used to map the genes controlling experimentally induced systemic lupus erythematosus (SLE). SLE was induced using two immunologic approaches: (1) immunization with the human monoclonal anti-DNA antibod...

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Bibliographic Details
Published in:Clinical immunology and immunopathology 1997-10, Vol.85 (1), p.28-34
Main Authors: Mozes, Edna, Alling, David, Miller, Matthew W., Payne, Susan M., Zinger, Heidy, Via, Charles S., Shearer, Gene M.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Antinuclear - administration & dosage
Antibodies, Monoclonal - administration & dosage
Antigen-Antibody Complex - metabolism
Autoimmunity
Biological and medical sciences
Chromosome Mapping
Disease Models, Animal
Female
Graft vs Host Disease - complications
Graft vs Host Disease - immunology
Humans
Immunization
Kidney - immunology
Lupus Erythematosus, Systemic - etiology
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Male
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
T-Lymphocytes, Cytotoxic - immunology
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Summary:The DBA/2 and C57BL/6 mouse strains, as well as the BXD RI lines derived from these strains, were used to map the genes controlling experimentally induced systemic lupus erythematosus (SLE). SLE was induced using two immunologic approaches: (1) immunization with the human monoclonal anti-DNA antibody expressing the 16/6Id, to which the DBA/2 strain is susceptible (responder) and the C57BL/6 strain is resistant (nonresponder); and (2) induction of autoimmune GVHD in B6D2F1 hosts by inoculation of parental DBA/2 (induces SLE) or C57BL/6 (does not induce SLE) T cells. By both approaches the BXD RI lines could be divided into distinct DBA/2-like and C57BL/6-like categories. Concordance of SLE induced by both methods was observed for susceptibility and resistance in 13/15 BXD lines (P< 0.005). The results suggest that at least two non-H-2 genes control susceptibility and resistance to experimentally induced SLE, one mapping to chromosome 7 and the other mapping to chromosome 14.
ISSN:0090-1229
1090-2341
DOI:10.1006/clin.1997.4423