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Evidence for a direct interaction of superoxide anion radical with carnosine
Using photochemiluminescence, the interaction between carnosine and superoxide anion was measured directly. Carnosine at physiological concentrations decreased the amplitude of luminol chemiluminescence like superoxide dismutase (SOD) did, and prolonged the lag‐period of the chemiluminescence simila...
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| Published in: | Biochemistry and molecular biology international 1997-09, Vol.43 (1), p.99-106 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3928-636aea33e3375f57411994712e4c4632705d24041a56093b964a1b9bd5be08753 |
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| container_end_page | 106 |
| container_issue | 1 |
| container_start_page | 99 |
| container_title | Biochemistry and molecular biology international |
| container_volume | 43 |
| creator | Klebanov, G. I. Teselkin, Yu.O. Babenkova, I. V. Popov, I. N. Levin, G. Tyulina, O. V. Boldyrev, A. A. Vladimirov, Yu.A. |
| description | Using photochemiluminescence, the interaction between carnosine and superoxide anion was measured directly. Carnosine at physiological concentrations decreased the amplitude of luminol chemiluminescence like superoxide dismutase (SOD) did, and prolonged the lag‐period of the chemiluminescence similar to the effect of ascorbic acid. From the interaction of nitro blue tetrazolium with superoxide anion generated by the xanthine oxidase system, the constant for interaction of carnosine with O2* was calculated to be 105 M‐1. sec‐1. The possible biological significance of the quenching of superoxide anion by carnosine is discussed. |
| doi_str_mv | 10.1080/15216549700203861 |
| format | article |
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The possible biological significance of the quenching of superoxide anion by carnosine is discussed.</description><identifier>ISSN: 1521-6543</identifier><identifier>ISSN: 1039-9712</identifier><identifier>EISSN: 1521-6551</identifier><identifier>DOI: 10.1080/15216549700203861</identifier><identifier>PMID: 9315287</identifier><language>eng</language><publisher>UK: Informa Healthcare</publisher><subject>Antioxidant effect ; Carnosine ; Carnosine - metabolism ; Carnosine - pharmacology ; Luminescent Measurements ; Luminol - metabolism ; Nitroblue Tetrazolium - metabolism ; Oxidation-Reduction ; Photochemiluminescence ; SOD ; Superoxide radical ; Superoxides - metabolism ; Xanthine Oxidase - metabolism</subject><ispartof>Biochemistry and molecular biology international, 1997-09, Vol.43 (1), p.99-106</ispartof><rights>Copyright © 1997 International Union of Biochemistry and Molecular Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3928-636aea33e3375f57411994712e4c4632705d24041a56093b964a1b9bd5be08753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9315287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klebanov, G. 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From the interaction of nitro blue tetrazolium with superoxide anion generated by the xanthine oxidase system, the constant for interaction of carnosine with O2* was calculated to be 105 M‐1. sec‐1. The possible biological significance of the quenching of superoxide anion by carnosine is discussed.</description><subject>Antioxidant effect</subject><subject>Carnosine</subject><subject>Carnosine - metabolism</subject><subject>Carnosine - pharmacology</subject><subject>Luminescent Measurements</subject><subject>Luminol - metabolism</subject><subject>Nitroblue Tetrazolium - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Photochemiluminescence</subject><subject>SOD</subject><subject>Superoxide radical</subject><subject>Superoxides - metabolism</subject><subject>Xanthine Oxidase - metabolism</subject><issn>1521-6543</issn><issn>1039-9712</issn><issn>1521-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFUDtPwzAQthColMIPYEDyxBaw41cssdCqPKQiljJHjnMRRmlc7IS2_55ErbowcMudvpd0H0LXlNxRkpF7KlIqBdeKkJSwTNITNB6wRApBT483Z-foIsYv0o8ieoRGmvVUpsZoMf9xJTQWcOUDNrh0AWyLXdNCMLZ1vsG-wrFbQ_DbXolNM2DBlM6aGm9c-4mtCY2ProFLdFaZOsLVYU_Qx9N8OXtJFu_Pr7PHRWKZTrNEMmnAMAaMKVEJxSnVmiuaArdcslQRUaaccGqEJJoVWnJDC12UogCSKcEm6Hafuw7-u4PY5isXLdS1acB3MVfDe4QOQroX2uBjDFDl6-BWJuxySvKhwfxPg73n5hDeFSsoj45DZT3_sOc3robd_4H5cvo2VYJoKSjL2C9jCXoL</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Klebanov, G. 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From the interaction of nitro blue tetrazolium with superoxide anion generated by the xanthine oxidase system, the constant for interaction of carnosine with O2* was calculated to be 105 M‐1. sec‐1. The possible biological significance of the quenching of superoxide anion by carnosine is discussed.</abstract><cop>UK</cop><pub>Informa Healthcare</pub><pmid>9315287</pmid><doi>10.1080/15216549700203861</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1521-6543 |
| ispartof | Biochemistry and molecular biology international, 1997-09, Vol.43 (1), p.99-106 |
| issn | 1521-6543 1039-9712 1521-6551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79315015 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Antioxidant effect Carnosine Carnosine - metabolism Carnosine - pharmacology Luminescent Measurements Luminol - metabolism Nitroblue Tetrazolium - metabolism Oxidation-Reduction Photochemiluminescence SOD Superoxide radical Superoxides - metabolism Xanthine Oxidase - metabolism |
| title | Evidence for a direct interaction of superoxide anion radical with carnosine |
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