Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant

The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African Am...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry and molecular biology international 1997-09, Vol.43 (1), p.227-231
Main Authors: Gainer, James V., Hunley, Tracy E., Kon, Valentina, Nadeau, John H., Muldowney, James A. S., Brown, Nancy J.
Format: Article
Language:English
Subjects:
Adult
angiotensin receptors
Black or African American
Black People - genetics
blacks
blood pressure
essential hypertension
Female
Genetic Variation
Genotype
Humans
Male
polymorphism (genetics)
Polymorphism, Genetic
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - genetics
renin‐angiotensin system
White People - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African American (n=99) and Caucasian (n=100) subjects were genotyped to determine the frequency of the C1166 variant. This study establishes the frequency of the C1166 variant in African Americans (0.05±0.01) and demonstrates a significantly lower frequency in African Americans compared with Caucasians (0.05 vs. 0.25, respectively, χ2=30.7, p
ISSN:1521-6543
1039-9712
1521-6551
DOI:10.1080/15216549700204001