Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant

The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African Am...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry and molecular biology international 1997-09, Vol.43 (1), p.227-231
Main Authors: Gainer, James V., Hunley, Tracy E., Kon, Valentina, Nadeau, John H., Muldowney, James A. S., Brown, Nancy J.
Format: Article
Language:English
Subjects:
Adult
angiotensin receptors
Black or African American
Black People - genetics
blacks
blood pressure
essential hypertension
Female
Genetic Variation
Genotype
Humans
Male
polymorphism (genetics)
Polymorphism, Genetic
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - genetics
renin‐angiotensin system
White People - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 231
container_issue 1
container_start_page 227
container_title Biochemistry and molecular biology international
container_volume 43
creator Gainer, James V.
Hunley, Tracy E.
Kon, Valentina
Nadeau, John H.
Muldowney, James A. S.
Brown, Nancy J.
description The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African American (n=99) and Caucasian (n=100) subjects were genotyped to determine the frequency of the C1166 variant. This study establishes the frequency of the C1166 variant in African Americans (0.05±0.01) and demonstrates a significantly lower frequency in African Americans compared with Caucasians (0.05 vs. 0.25, respectively, χ2=30.7, p
doi_str_mv 10.1080/15216549700204001
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79315074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79315074</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1912-8f9895e4e27a78fb733f6b09cdecdd934b1a076743375d27b81dc0b7d906b0a23</originalsourceid><addsrcrecordid>eNqFUMtOwzAQtBColMIHcEDyiVtgHcdxLHEpFY9KRUionCPH2dCgJA52SpW_J6VVLxzYy6x2Z0a7Q8glgxsGCdwyEbJYREoChBABsCMy3s6CWAh2fOgjfkrOvP-EoSSoERkpzgQHNiY4bT5K22Hjy4bO57TrW6Rz-oYG28462tqqr61rV6Wv6UCZFq40esAafxtPK7tBRwuHX2tsTE9tQbsV0hljcUy_tSt1052Tk0JXHi_2OCHvjw_L2XOweH2az6aLwDDFwiApVKIERhhKLZMik5wXcQbK5GjyXPEoYxpkLCPOpchDmSUsN5DJXMFA0yGfkOudb-vscI7v0rr0BqtKN2jXPpXbv2HQTwjbEY2z3jss0taVtXZ9yiDdRpv-iXbQXO3N11mN-UGxz3LY3-32m7LC_n_DdHn_ci8FqFiEEPIfJAaDTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79315074</pqid></control><display><type>article</type><title>Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant</title><source>Wiley</source><creator>Gainer, James V. ; Hunley, Tracy E. ; Kon, Valentina ; Nadeau, John H. ; Muldowney, James A. S. ; Brown, Nancy J.</creator><creatorcontrib>Gainer, James V. ; Hunley, Tracy E. ; Kon, Valentina ; Nadeau, John H. ; Muldowney, James A. S. ; Brown, Nancy J.</creatorcontrib><description>The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African American (n=99) and Caucasian (n=100) subjects were genotyped to determine the frequency of the C1166 variant. This study establishes the frequency of the C1166 variant in African Americans (0.05±0.01) and demonstrates a significantly lower frequency in African Americans compared with Caucasians (0.05 vs. 0.25, respectively, χ2=30.7, p&lt;&lt;0.001, 1 df).</description><identifier>ISSN: 1521-6543</identifier><identifier>ISSN: 1039-9712</identifier><identifier>EISSN: 1521-6551</identifier><identifier>DOI: 10.1080/15216549700204001</identifier><identifier>PMID: 9315301</identifier><language>eng</language><publisher>UK: Informa Healthcare</publisher><subject>Adult ; angiotensin receptors ; Black or African American ; Black People - genetics ; blacks ; blood pressure ; essential hypertension ; Female ; Genetic Variation ; Genotype ; Humans ; Male ; polymorphism (genetics) ; Polymorphism, Genetic ; Receptor, Angiotensin, Type 1 ; Receptor, Angiotensin, Type 2 ; Receptors, Angiotensin - genetics ; renin‐angiotensin system ; White People - genetics</subject><ispartof>Biochemistry and molecular biology international, 1997-09, Vol.43 (1), p.227-231</ispartof><rights>Copyright © 1997 International Union of Biochemistry and Molecular Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9315301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gainer, James V.</creatorcontrib><creatorcontrib>Hunley, Tracy E.</creatorcontrib><creatorcontrib>Kon, Valentina</creatorcontrib><creatorcontrib>Nadeau, John H.</creatorcontrib><creatorcontrib>Muldowney, James A. S.</creatorcontrib><creatorcontrib>Brown, Nancy J.</creatorcontrib><title>Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant</title><title>Biochemistry and molecular biology international</title><addtitle>Biochem Mol Biol Int</addtitle><description>The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African American (n=99) and Caucasian (n=100) subjects were genotyped to determine the frequency of the C1166 variant. This study establishes the frequency of the C1166 variant in African Americans (0.05±0.01) and demonstrates a significantly lower frequency in African Americans compared with Caucasians (0.05 vs. 0.25, respectively, χ2=30.7, p&lt;&lt;0.001, 1 df).</description><subject>Adult</subject><subject>angiotensin receptors</subject><subject>Black or African American</subject><subject>Black People - genetics</subject><subject>blacks</subject><subject>blood pressure</subject><subject>essential hypertension</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>polymorphism (genetics)</subject><subject>Polymorphism, Genetic</subject><subject>Receptor, Angiotensin, Type 1</subject><subject>Receptor, Angiotensin, Type 2</subject><subject>Receptors, Angiotensin - genetics</subject><subject>renin‐angiotensin system</subject><subject>White People - genetics</subject><issn>1521-6543</issn><issn>1039-9712</issn><issn>1521-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFUMtOwzAQtBColMIHcEDyiVtgHcdxLHEpFY9KRUionCPH2dCgJA52SpW_J6VVLxzYy6x2Z0a7Q8glgxsGCdwyEbJYREoChBABsCMy3s6CWAh2fOgjfkrOvP-EoSSoERkpzgQHNiY4bT5K22Hjy4bO57TrW6Rz-oYG28462tqqr61rV6Wv6UCZFq40esAafxtPK7tBRwuHX2tsTE9tQbsV0hljcUy_tSt1052Tk0JXHi_2OCHvjw_L2XOweH2az6aLwDDFwiApVKIERhhKLZMik5wXcQbK5GjyXPEoYxpkLCPOpchDmSUsN5DJXMFA0yGfkOudb-vscI7v0rr0BqtKN2jXPpXbv2HQTwjbEY2z3jss0taVtXZ9yiDdRpv-iXbQXO3N11mN-UGxz3LY3-32m7LC_n_DdHn_ci8FqFiEEPIfJAaDTQ</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Gainer, James V.</creator><creator>Hunley, Tracy E.</creator><creator>Kon, Valentina</creator><creator>Nadeau, John H.</creator><creator>Muldowney, James A. S.</creator><creator>Brown, Nancy J.</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant</title><author>Gainer, James V. ; Hunley, Tracy E. ; Kon, Valentina ; Nadeau, John H. ; Muldowney, James A. S. ; Brown, Nancy J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1912-8f9895e4e27a78fb733f6b09cdecdd934b1a076743375d27b81dc0b7d906b0a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>angiotensin receptors</topic><topic>Black or African American</topic><topic>Black People - genetics</topic><topic>blacks</topic><topic>blood pressure</topic><topic>essential hypertension</topic><topic>Female</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>polymorphism (genetics)</topic><topic>Polymorphism, Genetic</topic><topic>Receptor, Angiotensin, Type 1</topic><topic>Receptor, Angiotensin, Type 2</topic><topic>Receptors, Angiotensin - genetics</topic><topic>renin‐angiotensin system</topic><topic>White People - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gainer, James V.</creatorcontrib><creatorcontrib>Hunley, Tracy E.</creatorcontrib><creatorcontrib>Kon, Valentina</creatorcontrib><creatorcontrib>Nadeau, John H.</creatorcontrib><creatorcontrib>Muldowney, James A. S.</creatorcontrib><creatorcontrib>Brown, Nancy J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry and molecular biology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gainer, James V.</au><au>Hunley, Tracy E.</au><au>Kon, Valentina</au><au>Nadeau, John H.</au><au>Muldowney, James A. S.</au><au>Brown, Nancy J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant</atitle><jtitle>Biochemistry and molecular biology international</jtitle><addtitle>Biochem Mol Biol Int</addtitle><date>1997-09</date><risdate>1997</risdate><volume>43</volume><issue>1</issue><spage>227</spage><epage>231</epage><pages>227-231</pages><issn>1521-6543</issn><issn>1039-9712</issn><eissn>1521-6551</eissn><abstract>The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African American (n=99) and Caucasian (n=100) subjects were genotyped to determine the frequency of the C1166 variant. This study establishes the frequency of the C1166 variant in African Americans (0.05±0.01) and demonstrates a significantly lower frequency in African Americans compared with Caucasians (0.05 vs. 0.25, respectively, χ2=30.7, p&lt;&lt;0.001, 1 df).</abstract><cop>UK</cop><pub>Informa Healthcare</pub><pmid>9315301</pmid><doi>10.1080/15216549700204001</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1521-6543
ispartof Biochemistry and molecular biology international, 1997-09, Vol.43 (1), p.227-231
issn 1521-6543
1039-9712
1521-6551
language eng
recordid cdi_proquest_miscellaneous_79315074
source Wiley
subjects Adult
angiotensin receptors
Black or African American
Black People - genetics
blacks
blood pressure
essential hypertension
Female
Genetic Variation
Genotype
Humans
Male
polymorphism (genetics)
Polymorphism, Genetic
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - genetics
renin‐angiotensin system
White People - genetics
title Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T01%3A10%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angiotensin%20II%20type%20I%20Receptor%20polymorphism%20in%20African%20Americans%20lower%20frequency%20of%20the%20C1166%20variant&rft.jtitle=Biochemistry%20and%20molecular%20biology%20international&rft.au=Gainer,%20James%20V.&rft.date=1997-09&rft.volume=43&rft.issue=1&rft.spage=227&rft.epage=231&rft.pages=227-231&rft.issn=1521-6543&rft.eissn=1521-6551&rft_id=info:doi/10.1080/15216549700204001&rft_dat=%3Cproquest_cross%3E79315074%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c1912-8f9895e4e27a78fb733f6b09cdecdd934b1a076743375d27b81dc0b7d906b0a23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=79315074&rft_id=info:pmid/9315301&rfr_iscdi=true