Prophylaxis of encephalopathies and risk factors of atherogenesis development in the postresuscitation period in rats by means of succinic acid

The effect of oral administration of succinic acid was studied in 66 rats exposed to 10 min cardiac arrest with further resuscitation. A total of 30 mg/kg of the drug were administered daily for 5 days starting with day 3 up to day 7 after resuscitation. The experiments have revealed that treatment...

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Bibliographic Details
Published in:Resuscitation 1997-10, Vol.35 (2), p.165-170
Main Authors: Gurvitch, A.M, Mutuskina, E.A, Zarzhetsky, Yu.V, Trubina, I.E, Avruschenko, M.Sh, Pylova, S.I, Volkov, A.V, Lazareva, N.A, Stepanichev, M.Yu, Onufriev, M.V, Gulyaeva, N.V
Format: Article
Language:English
Subjects:
Animals
Arteriosclerosis - epidemiology
Arteriosclerosis - etiology
Arteriosclerosis - prevention & control
Atherogenesis
Behavior, Animal - drug effects
Brain Ischemia - etiology
Brain Ischemia - prevention & control
Cardiac arrest
Cardiopulmonary Resuscitation - adverse effects
Disease Models, Animal
Heart Arrest - drug therapy
Heart Arrest - therapy
Lipoproteins - blood
Male
Postresuscitation encephalopathy
Rats
Rats, Mutant Strains
Reference Values
Risk Factors
Succinic acid
Succinic Acid - administration & dosage
Succinic Acid - therapeutic use
Survival Rate
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Summary:The effect of oral administration of succinic acid was studied in 66 rats exposed to 10 min cardiac arrest with further resuscitation. A total of 30 mg/kg of the drug were administered daily for 5 days starting with day 3 up to day 7 after resuscitation. The experiments have revealed that treatment with succinic acid caused normalization of the orienting behavior in an `open field' test, decrease of the intensity of response to electric shock, normalization of free radical formation in the brain and serum and reduced cerebral morphological changes. The succinic acid prevented the increase of cholesterol, triglyceride and low density lipoproteins in the blood. The data suggested that after additional trials the succinic acid could be used to prevent development of postresuscitation encephalopathies (3 months after reanimation).
ISSN:0300-9572
1873-1570
DOI:10.1016/S0300-9572(97)00045-2