Alteration of platelet aggregation in patients with thyroid disorders

To determine whether Graves' disease or primary hypothyroidism influence platelet function, we evaluated platelet aggregation in the platelet-rich plasma (PRP) from such patients. Platelet aggregation induced by adenosine diphosphate (ADP) in blood obtained from patients with untreated Graves&#...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 1997-10, Vol.46 (10), p.1128-1131
Main Authors: Masunaga, Rumi, Nagasaka, Akio, Nakai, Akira, Kotake, Motoko, Sawai, Yoshikuni, Oda, Naohisa, Mokuno, Takehiko, Shimazaki, Keiko, Hayakawa, Nobuki, Kato, Ritsuko, Hirano, Erika, Hagiwara, Masatoshi, Hidaka, Hiroyoshi
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - pharmacology
Adult
Biological and medical sciences
Endocrinopathies
Female
Graves Disease - blood
Humans
Hypothyroidism - blood
In Vitro Techniques
Male
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Platelet Aggregation - drug effects
Reference Values
Regression Analysis
Thyroid. Thyroid axis (diseases)
Thyrotropin - blood
Thyroxine - blood
Triiodothyronine - blood
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Summary:To determine whether Graves' disease or primary hypothyroidism influence platelet function, we evaluated platelet aggregation in the platelet-rich plasma (PRP) from such patients. Platelet aggregation induced by adenosine diphosphate (ADP) in blood obtained from patients with untreated Graves' disease was significantly lower than normal, whereas that in patients with untreated primary hypothyroidism was relatively increased. The magnitude of platelet aggregation induced by collagen in both groups of patients resembled that induced by ADP. However, significant differences were evident between the two diseases ( P < .05). In addition, we observed a significant inverse correlation between the extent of platelet aggregation and plasma levels of thyroid hormones (triiodothyronine [T 3], thyroxine [T 4], and free T 3). Platelet aggregation returned to normal when the euthyroid condition was obtained in the patients following administration of antithyroid drugs or thyroid hormone. The findings are consistent with the possibility that thyroid hormones influence platelet aggregation partly via inhibition of myosin light-chain kinase (MLCK).
ISSN:0026-0495
1532-8600
DOI:10.1016/S0026-0495(97)90203-1