[ 123I]-6-deoxy-6-iodo- d-glucose (6DIG): A potential tracer of glucose transport

A glucose analogue labelled with iodine-123 in position 6 has been synthesized: [ 123I]-6-deoxy-6-iodo- d-glucose (6DIG). The aim of this study was to examine its biological behaviour in order to assess whether it could be used to evaluate glucose transport with SPECT. To establish whether 6DIG ente...

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Bibliographic Details
Published in:Nuclear medicine and biology 1997-08, Vol.24 (6), p.527-534
Main Authors: Henry, Christelle, Koumanov, Françoise, Ghezzi, Catherine, Morin, Christophe, Mathieu, Jean-Paul, Vidal, Michel, de Leiris, Joël, Comet, Michel, Fagret, Daniel
Format: Article
Language:English
Subjects:
3-O-methyl- d-glucose
Animals
Biological and medical sciences
Biological Transport
Cells, Cultured
Contrast media. Radiopharmaceuticals
Deoxyglucose - analogs & derivatives
Erythrocytes - metabolism
Female
Glucose - metabolism
Glucose transport
Humans
Iodinated analogues of glucose
Iodine Radioisotopes
Male
Medical sciences
Mice
Myocardium - metabolism
Pharmacology. Drug treatments
Radiopharmaceuticals
Rats
Rats, Wistar
SPECT
Tissue Distribution
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Summary:A glucose analogue labelled with iodine-123 in position 6 has been synthesized: [ 123I]-6-deoxy-6-iodo- d-glucose (6DIG). The aim of this study was to examine its biological behaviour in order to assess whether it could be used to evaluate glucose transport with SPECT. To establish whether 6DIG enters the cells using the glucose transporter, four biological models have been used: human erythrocytes in suspension, neonatal rat cardiomyocytes in culture, isolated perfused rat hearts, and biodistribution in mice. 6DIG competed with d-glucose to enter the cells and its entry was increased by insulin and inhibited in the presence of cytochalasin B. The biological behaviour of 6DIG was similar to that of 3-O-methyl- d-glucose. 6DIG is a tracer of glucose transport which is very promising for clinical studies.
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(97)00037-1