Specific antiplatelet glycoprotein autoantibodies are associated with the thrombocytopenia of primary antiphospholipid syndrome

Thrombocytopenia is a frequent complication of primary antiphospholipid syndrome (PAPL) and has been attributed to antibodies directed against platelet glycoproteins (Gp) and also to antiphospholipid antibodies. We tested patients with PAPL with and without thrombocytopenia for specific antiplatelet...

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Bibliographic Details
Published in:British journal of haematology 1997-09, Vol.98 (4), p.873-879
Main Authors: Godeau, Bertrand, Piette, Jean‐Charles, Fromont, Patricia, Intrator, Liliane, Schaeffer, Annette, Bierling, Philippe
Format: Article
Language:English
Subjects:
Adult
Antibodies, Anticardiolipin - analysis
antiphospholipid antibody
Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - immunology
Autoantibodies - analysis
autoimmune thrombocytopenic purpura
Biological and medical sciences
Blood Platelets - immunology
Enzyme-Linked Immunosorbent Assay
Female
General aspects
Humans
Immunoblotting
Immunoglobulin Fab Fragments - immunology
Immunoglobulin G - analysis
Immunopathology
MAIPA
Male
Medical sciences
Platelet Membrane Glycoproteins - immunology
primary antiphospholipid syndrome
thrombocytopenia
Thrombocytopenia - complications
Thrombocytopenia - immunology
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Summary:Thrombocytopenia is a frequent complication of primary antiphospholipid syndrome (PAPL) and has been attributed to antibodies directed against platelet glycoproteins (Gp) and also to antiphospholipid antibodies. We tested patients with PAPL with and without thrombocytopenia for specific antiplatelet autoantibodies. Platelet autoantibodies were detected by means of platelet immunoassays which included MAIPA with a panel of monoclonal antibodies directed against all the platelet Gps known to be possible targets for platelet autoantibodies. A high prevalence of serum platelet antibodies was found in patients with thrombocytopenia (73%, 11/15 patients) whereas antiplatelet antibody was detected in only one of the 10 control patients (P 
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1997.3063123.x