Exercise Training in Aging: Hemodynamic, Metabolic, and Oxidative Stress Evaluations

The effects of exercise training on hemodynamic and metabolic parameters as well as on responses to oxidative stress in aged individuals are controversial. The aim of the present study was to investigate changes in heart hate, mean arterial pressure, vasoreactivity, and plasma levels of insulin and...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1997-09, Vol.30 (3), p.767-771
Main Authors: De Angelis, K.L.D, Oliveira, A.R, Werner, A, Bock, P, Bello-Klein, A, Fernandes, T.G, Bello, A.A, Irigoyen, NA
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Biological and medical sciences
Blood Glucose - analysis
Fundamental and applied biological sciences. Psychology
Hemodynamics
Hemodynamics. Rheology
Hydrogen Peroxide - pharmacology
Insulin - blood
Male
Oxidative Stress
Physical Conditioning, Animal
Rats
Rats, Wistar
Vertebrates: cardiovascular system
Citations: Items that this one cites
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Summary:The effects of exercise training on hemodynamic and metabolic parameters as well as on responses to oxidative stress in aged individuals are controversial. The aim of the present study was to investigate changes in heart hate, mean arterial pressure, vasoreactivity, and plasma levels of insulin and glucose in male aged Wistar rats submitted to exercise training for 11 weeks (1 h/d; 5 d/wk) in a treadmill. The isolated heart was perfused by H2 O2, and oxidative stress was evaluated using thiobarbituric acid reactive substances. Cardiovascular functions were recorded with a data acquisition system (CODAS, 1 kHz). Trained aged rats were bradycardic as compared with sedentary aged rats (298 +/- 7 versus 336 +/- 16 bpm) but presented similar mean arterial pressure and vasoreactivity and plasma levels of insulin and of glucose, which were quantified by radioimmunoassay and colorimetric enzymatic test. Plasma levels of insulin and of glucose ratio were increased in trained aged rats (6.9 +/- 0.7 versus 3.5 +/- 0.4 in sedentary aged rats), and the response to oxidative stress was decreased (0.4 +/- 0.1 versus 0.7 +/- 0,1 nmol/mg protein in sedentary aged rats). These results showed that exercise training produced a lower resting heart rate as well as changes in metabolic and oxidative responses. This suggests a higher myocardium protection of trained than sedentary aged rats. (Hypertension. 1997;30[part 2]:767-771.)
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.30.3.767