Importance of location and timing of electrical stimuli in terminating sustained functional reentry in isolated swine ventricular tissues : Evidence in support of a small reentrant circuit

In excitable chemical media, a spiral wave is formed by reentrant excitation around a core and normal propagation away from the core. Whether or not this applies to cardiac muscle is unknown. In six isolated swine ventricular slices, we induced sustained episodes of functional reentry with a station...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1997-09, Vol.96 (6), p.2048-2060
Main Authors: KAMJOO, K, UCHIDA, T, IKEDA, T, FISHBEIN, M. C, GARFINKEL, A, WEISS, J. N, KARAGUEUZIAN, H. S, CHEN, P.-S
Format: Article
Language:English
Subjects:
Animals
Anti-Arrhythmia Agents - pharmacology
Benzopyrans - pharmacology
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Cromakalim
Electric Countershock
Electrocardiography
Electrophysiology
Heart
Heart Conduction System - drug effects
Heart Conduction System - physiopathology
In Vitro Techniques
Medical sciences
Muscle Fibers, Skeletal - drug effects
Muscle Fibers, Skeletal - physiology
Pacemaker, Artificial
Pyrroles - pharmacology
Swine
Tachycardia, Atrioventricular Nodal Reentry - drug therapy
Tachycardia, Atrioventricular Nodal Reentry - physiopathology
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Summary:In excitable chemical media, a spiral wave is formed by reentrant excitation around a core and normal propagation away from the core. Whether or not this applies to cardiac muscle is unknown. In six isolated swine ventricular slices, we induced sustained episodes of functional reentry with a stationary core. A train of stimuli applied away from the core (7- to 8-mm distance) and near the core (within 1.6 mm) terminated 5 of 24 and 14 of 17 episodes of reentry, respectively (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.96.6.2048