Papillomavirus Is Resistant to Desiccation

There is strong epidemiologic evidence for sexual transmission of high-risk genital human papillomavirus (HPV) types. However, it is unclear if infection may also be transmitted indirectly via fomites. To assess this possibility, the in vitro infectivity after desiccation was compared for pseudotype...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-10, Vol.176 (4), p.1076-1079
Main Authors: Roden, Richard B. S., Lowy, Douglas R., Schiller, John T.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bovine papillomavirus 1 - growth & development
Bovine papillomavirus 1 - immunology
Bovine papillomavirus 1 - pathogenicity
Cell extracts
Cells, Cultured
Concise Communications
Desiccation
Edetic Acid - pharmacology
Epidemiology
Ethanol
Ethanol - pharmacology
Fomites
Fundamental and applied biological sciences. Psychology
Genitalia
Heating - adverse effects
Human papillomavirus 16
Infections
Microbiology
Neutralization Tests
Papillomaviridae - growth & development
Papillomaviridae - immunology
Papillomaviridae - pathogenicity
Papillomavirus Infections - transmission
Sexual transmission
Time Factors
Tumor Virus Infections - transmission
Virions
Virology
Viruses
Warts
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Summary:There is strong epidemiologic evidence for sexual transmission of high-risk genital human papillomavirus (HPV) types. However, it is unclear if infection may also be transmitted indirectly via fomites. To assess this possibility, the in vitro infectivity after desiccation was compared for pseudotype HPV-16 virions, a model for high-risk type genital HPV, and bovine papillomavirus type 1 (BPV-1), a papillomavirus known to be transmitted via fomites. The 2 viruses had similar resistance to desiccation in cell extracts, retaining ∼100%, 50%, and 30% of infectivity when dehydrated for 1, 3, and 7 days, respectively, at room temperature. Pseudotype HPV-16 and BPV in cell extracts were completely inactivated by autoclave treatment and susceptible to 70%ethanol but were resistant to EDTA or incubation at 56°C for 1 h. The data suggest that further study of nonsexual spread of high-risk genital HPV via fomites is warranted.
ISSN:0022-1899
1537-6613
DOI:10.1086/516515