A Commentary on the Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease

Apart from providing a potential framework for a universally acceptable protocol for the pathological diagnosis of Alzheimer’s disease, the Working Party has dispelled one of the major myths of so-called normal aging, namely that minor degrees of Alzheimer-type change (i.e., plaques and tangles) are...

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Bibliographic Details
Published in:Neurobiology of aging 1997-07, Vol.18 (4), p.S51-S52
Main Author: Mann, D.M.A
Format: Article
Language:English
Subjects:
Aged
Aging
Aging - pathology
Alzheimer Disease - diagnosis
Alzheimer Disease - pathology
Alzheimer’s disease
Amyloid
Biological and medical sciences
Brain - pathology
Consensus Development Conferences as Topic
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Guidelines as Topic
Humans
Medical sciences
Neurofibrillary Tangles - pathology
Neurology
Plaque, Amyloid - pathology
Plaques
Severity of Illness Index
Tangles
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Summary:Apart from providing a potential framework for a universally acceptable protocol for the pathological diagnosis of Alzheimer’s disease, the Working Party has dispelled one of the major myths of so-called normal aging, namely that minor degrees of Alzheimer-type change (i.e., plaques and tangles) are not the product of growing older alone but should always be regarded as pathological, as they probably represent the tissue substrate of incipient Alzheimer’s disease. Establishment of the pathological criteria for such preclinical disease will be of equal importance as that associated with clinical change.
ISSN:0197-4580
1558-1497
DOI:10.1016/S0197-4580(97)00069-9