Genetic Similarity among Mycobacterium avium Isolates from Blood, Stool, and Sputum of Persons with AIDS

Large-restriction-fragment pattern comparison of Mycobacterium avium from 85 blood, stool, and respiratory specimens from 25 human immunodeficiency virus-infected San Francisco patients revealed 4 strains that infected multiple people (3 groups of 2 patients and 1 group of 3 patients). Most patients...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-10, Vol.176 (4), p.976-983
Main Authors: Mazurek, Gerald H., Chin, Daniel P., Hartman, Sandra, Reddy, Venkat, Horsburgh, C. Robert, Green, Timothy A., Yajko, David M., Hopewell, Philip C., Reingold, Arthur L., Crawford, Jack T.
Format: Article
Language:English
Subjects:
AIDS
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - microbiology
AIDS/HIV
Bacteremia
Bacterial diseases
Biological and medical sciences
Blood
California - epidemiology
DNA
DNA, Bacterial - analysis
Feces - microbiology
Human bacterial diseases
Humans
Infections
Infectious diseases
Mazurka
Medical sciences
Molecular Epidemiology
Mycobacterium avium
Mycobacterium avium complex
Mycobacterium avium Complex - genetics
Mycobacterium avium-intracellulare Infection - blood
Mycobacterium avium-intracellulare Infection - epidemiology
Mycobacterium avium-intracellulare Infection - genetics
Mycobacterium tuberculosis
Polymorphism, Restriction Fragment Length
San Francisco - epidemiology
Specimens
Sputum - microbiology
Tuberculosis and atypical mycobacterial infections
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Summary:Large-restriction-fragment pattern comparison of Mycobacterium avium from 85 blood, stool, and respiratory specimens from 25 human immunodeficiency virus-infected San Francisco patients revealed 4 strains that infected multiple people (3 groups of 2 patients and 1 group of 3 patients). Most patients harbored a single M. avium strain, but 2 strains were recovered from 8 patients. The significance of recovering 2 strains is not clear, since the second strain was seldom recovered more than once. The strain recovered from blood was recovered from stool of 4 patients and respiratory secretions of 6 patients >4 weeks before detection of bacteremia, indicating that the intestinal and respiratory tracts are entry portals from which M. avium can disseminate. M. avium from 21 cities outside of California served as controls. Thus, a single M. avium strain can cause disseminated infection in multiple patients. This may represent infection from a common environmental source or person-to-person spread.
ISSN:0022-1899
1537-6613
DOI:10.1086/516509