Rheumatoid arthritis complicated by infection with the human immunodeficiency virus and the development of Sjögren's syndrome

A patient with seropositive rheumatoid arthritis became infected with the human immunodeficiency virus (HIV) through heterosexual transmission. After the primary phase of the HIV infection, persistent lymphadenopathy, leukopenia, and thrombocytopenia developed. Over the ensuing 3 years, the signs an...

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Bibliographic Details
Published in:Arthritis and rheumatism 1989-11, Vol.32 (11), p.1453-1457
Main Authors: Calabrese, Leonard H., Wilke, William S., Perkins, Alvin D., Tubbs, Raymond R.
Format: Article
Language:English
Subjects:
AIDS/HIV
Antigens, CD - analysis
Antigens, Differentiation, T-Lymphocyte
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - pathology
Biological and medical sciences
CD4 Antigens - analysis
CD4-Positive T-Lymphocytes
CD8 Antigens
Diseases of the osteoarticular system
Female
HIV Infections - complications
HIV Infections - immunology
HIV Infections - pathology
Humans
Inflammatory joint diseases
Medical sciences
Middle Aged
Salivary Glands - immunology
Salivary Glands - pathology
Sjogren's Syndrome - etiology
Sjogren's Syndrome - immunology
Sjogren's Syndrome - pathology
T-Lymphocytes, Regulatory
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Summary:A patient with seropositive rheumatoid arthritis became infected with the human immunodeficiency virus (HIV) through heterosexual transmission. After the primary phase of the HIV infection, persistent lymphadenopathy, leukopenia, and thrombocytopenia developed. Over the ensuing 3 years, the signs and symptoms of inflammatory polyarthritis completely disappeared, and severe Sjögren's syndrome developed. HIV and its associated immune dysfunction may be responsible for these events.
ISSN:0004-3591
1529-0131
DOI:10.1002/anr.1780321115