Adrenergic neurons and short proprioceptive feedback loops involved in the integration of cardiac function in the rat

Serial cryostat and paraffin-embedded sections through the atrioventricular junction of the rat heart were studied at the light-microscopic level after indirect immunohistochemical staining (tyrosine hydroxylase, neuropeptide Y, C-terminal flanking peptide of neuropeptide Y immunoreactivities) or si...

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Bibliographic Details
Published in:Cell and tissue research 1989-11, Vol.258 (2), p.381-385
Main Authors: MORAVEC, M, MORAVEC, J
Format: Article
Language:English
Subjects:
Adrenergic Fibers - metabolism
Adrenergic Fibers - physiology
Animals
Atrioventricular Node - cytology
Atrioventricular Node - metabolism
Atrioventricular Node - physiology
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Heart Conduction System - metabolism
Male
Neuropeptide Y - metabolism
Proprioception
Rats
Rats, Inbred Strains
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Tyrosine 3-Monooxygenase - metabolism
Vertebrates: nervous system and sense organs
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Summary:Serial cryostat and paraffin-embedded sections through the atrioventricular junction of the rat heart were studied at the light-microscopic level after indirect immunohistochemical staining (tyrosine hydroxylase, neuropeptide Y, C-terminal flanking peptide of neuropeptide Y immunoreactivities) or silver impregnation. The distribution of these immunoreactivities in the Hissian ganglion (Moravec and Moravec 1984) as well as the relationships of the Hissian ganglion cells with the surrounding structures have been studied to assess its function. The results suggest that the Hissian ganglion is composed of large multipolar neurons displaying both tyrosine hydroxylase (TH) and related peptide (neuropeptide Y. C-terminal flanking peptide of neuropeptide Y) immunoreactivities. The dendritic projections of these adrenergic cells penetrate the reticular portion of the atrioventricular node and the upper segments of the interventricular septum where they constitute sensory-like corpuscles. The hypothesis that the adrenergic neurons of the atrioventricular junction are involved in short proprioceptive feedback loops necessary for beat-to-beat modulation of cardiac excitability and intracardiac conduction can thus be suggested.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00239458