The successful use of protein C concentrate during pregnancy in a patient with type 1 protein C deficiency, previous thrombosis and recurrent fetal loss

• Published in: British journal of haematology 1997-09, Vol.98 (3), p.660-661
• Main Authors: Richards, E. M., Makris, M., Preston, F. E.
• Format: Article
• Language: English
• Subjects: Abortion, Habitual - prevention & control; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Diseases of mother, fetus and pregnancy; Female; fetal loss; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Pregnancy; Pregnancy Complications, Cardiovascular - prevention & control; Pregnancy Complications, Hematologic - prevention & control; Pregnancy Trimester, First; Pregnancy Trimester, Third; Pregnancy. Fetus. Placenta; Protein C - therapeutic use; protein C concentrate; Protein C Deficiency; Thromboembolism - prevention & control; thrombophilia; Transfusions. Complications. Transfusion reactions. Cell and gene therapy
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1046/j.1365-2141.1997.2873100.x

The risks of venous thrombosis and fetal loss are increased in patients with protein C deficiency. We describe a patient with a history of thrombosis and recurrent fetal loss who was found to have type 1 protein C deficiency. In view of her history and intolerance of heparin preparations, she was treated with protein C concentrate during the first and third trimesters of her seventh pregnancy. The patient suffered no thromboembolic event during this pregnancy and gave birth to a healthy infant. The implications of the success of this therapeutic strategy are discussed.