Peptidomimetic Regulation of Growth Hormone Secretion

• Published in: Endocrine reviews 1997-10, Vol.18 (5), p.621-645
• Main Authors: Smith, Roy G, Van der Ploeg, Lex H. T, Howard, Andrew D, Feighner, Scott D, Cheng, Kang, Hickey, Gerard J, Wyvratt, Matthew J, Fisher, Mike H, Nargund, Ravi P, Patchett, Arthur A
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Drug Design; Fundamental and applied biological sciences. Psychology; Growth Hormone - secretion; Growth Hormone-Releasing Hormone - pharmacology; Growth hormones; Hormones and neuropeptides. Regulation; Humans; Hypothalamus. Hypophysis. Epiphysis. Urophysis; Indoles - metabolism; Indoles - pharmacology; Neuropeptides - chemical synthesis; Neuropeptides - pharmacology; RNA, Messenger - analysis; Somatostatin - pharmacology; Spiro Compounds - metabolism; Spiro Compounds - pharmacology; Vertebrates: endocrinology
• ISSN: 0163-769X; 1945-7189
• DOI: 10.1210/edrv.18.5.0316

I. Introduction II. Identification of Peptidomimetic GH Secretagogues A. Mechanism of action of GHRH, GHRP-6, and somatostatin B. In vitro assays III. Molecular Design by Medicinal Chemistry A. Benzolactams and L-692,429 B. Spiroindanes and MK-0677 C. Isonipecotic acid peptidomimetics IV. Characterization of the MK-0677 Receptor A. Pituitary gland B. Hypothalamus V. Signal Transduction Pathway VI. Cloning the GH Secretagogue Receptor A. Chromosomal localization VII. Action of the Peptidomimetic GH Secretagogues in the Central Nervous System VIII. Peptidomimetic GH Secretagogues in Vivo A. Animal models B. Clinical studies in humans IX. Regulation of Pulsatile GH Release A. GHRH and somatostatin B. The role of GHS-R X. Concluding Comments