Diffuse proliferative glomerulonephritis and acute renal failure associated with acute staphylococcal osteomyelitis

A 72-year-old man developed acute renal failure after coronary bypass surgery that had been complicated by sternal osteomyelitis caused by the Staphylococcus aureus bacterium. Bacteremia and sepsis were not present. Renal biopsy demonstrated a florid, diffuse, proliferative glomerulonephritis with g...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Society of Nephrology 1997-10, Vol.8 (10), p.1633-1639
Main Authors: GRIFFIN, M. D, BJÖRNSSON, J, ERICKSON, S. B
Format: Article
Language:English
Subjects:
Acute Kidney Injury - etiology
Acute Kidney Injury - therapy
Aged
Antigen-Antibody Complex - metabolism
Biological and medical sciences
Coronary Artery Bypass - adverse effects
Diseases of the osteoarticular system
Glomerulonephritis
Glomerulonephritis - etiology
Glomerulonephritis - immunology
Glomerulonephritis - pathology
Humans
Male
Medical sciences
Miscellaneous. Osteoarticular involvement in other diseases
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Osteomyelitis - complications
Osteomyelitis - etiology
Postoperative Complications - etiology
Staphylococcal Infections - complications
Staphylococcal Infections - etiology
Surgical Wound Infection - etiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 72-year-old man developed acute renal failure after coronary bypass surgery that had been complicated by sternal osteomyelitis caused by the Staphylococcus aureus bacterium. Bacteremia and sepsis were not present. Renal biopsy demonstrated a florid, diffuse, proliferative glomerulonephritis with glomerular immune complex deposition. Management included hemodialysis, prolonged antibiotic therapy, and repeated surgical debridement. Spontaneous recovery of renal function occurred after eradication of infection and final surgical wound repair. The relationship between acute bacterial infections and glomerulonephritis and, in particular, the causal role of staphylococcal antigens in the pathogenesis of such lesions is discussed.
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.V8101633