Tumour blood flow and partition coefficients : correlation with grade of cerebral gliomas using xenon-enhanced computed tomography

It is possible to underestimate the grade of nonenhancing cerebral tumours on conventional contrast-enhanced MRI or CT. Differentiation of high- and low-grade gliomas by measurement of the brain-blood partition coefficient lambda (T lambda) with Xe-enhanced CT (XeCT) has been reported. We assessed t...

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Bibliographic Details
Published in:Neuroradiology 1997-09, Vol.39 (9), p.627-632
Main Authors: NASEL, C, RÖSSLER, K, HEIMBERGER, K, GÖRZER, H, LASSMANN, H, SCHINDLER, E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Astrocytoma - blood supply
Astrocytoma - diagnosis
Astrocytoma - pathology
Biological and medical sciences
Biopsy
Blood-Brain Barrier - physiology
Brain - blood supply
Brain - pathology
Contrast Media
Female
Glioma - blood supply
Glioma - diagnosis
Glioma - pathology
Humans
Male
Medical sciences
Middle Aged
Neurology
Oligodendroglioma - blood supply
Oligodendroglioma - diagnosis
Oligodendroglioma - pathology
Sensitivity and Specificity
Stereotaxic Techniques
Supratentorial Neoplasms - blood supply
Supratentorial Neoplasms - diagnosis
Supratentorial Neoplasms - pathology
Tomography, X-Ray Computed
Tumors of the nervous system. Phacomatoses
Xenon
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Summary:It is possible to underestimate the grade of nonenhancing cerebral tumours on conventional contrast-enhanced MRI or CT. Differentiation of high- and low-grade gliomas by measurement of the brain-blood partition coefficient lambda (T lambda) with Xe-enhanced CT (XeCT) has been reported. We assessed the practical applications of XeCT in suspected low-grade astrocytomas. We examined 15 patients with tumours which showed no contrast enhancement on conventional MRI and CT, using XeCT. Tumour blood flow (TBF) and T lambda were calculated. Fourteen patients underwent surgery, one patient had a biopsy. We recognized three histological groups. While T lambda differed significantly between them, TBF did not. Group 1 contained grade II-III astrocytomas and T lambda was 0.77; group 2 contained grade I-II astrocytomas with T lambda 1.14, and group 3 four oligodendrogliomas in which a T lambda of 1.50 was found.
ISSN:0028-3940
1432-1920
DOI:10.1007/s002340050481