Experimental antitumor activity of the Ce(IV)-mitoxantrone complex and its interaction with deoxyribonucleic acid

The Ce(IV)-mitoxantrone complex exhibits a higher lethality to Ehrlich ascites tumor cells than that of the free drug and shows stronger inhibition ability on the DNA synthesis of the tumor cells. Thus the Ce(IV)-mitoxantrone complex may become a more potent antitumor drug than mitoxantrone. The dif...

Full description

Saved in:
Bibliographic Details
Published in:Journal of inorganic biochemistry 1997-11, Vol.68 (2), p.117-121
Main Authors: Wang, Hongfei, Yang, Pin, Tian, Yanni, Zhang, Zhigang, Zhao, Chungui
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Survival - drug effects
Cerium - pharmacology
Circular Dichroism
DNA - chemistry
DNA - drug effects
DNA, Neoplasm - biosynthesis
DNA, Neoplasm - drug effects
Drug Screening Assays, Antitumor
Electrochemistry
Electrophoresis - methods
Mice
Mitoxantrone - analogs & derivatives
Mitoxantrone - chemistry
Mitoxantrone - pharmacology
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Spectrophotometry - methods
Thymidine - metabolism
Tumor Cells, Cultured
Ultraviolet Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Ce(IV)-mitoxantrone complex exhibits a higher lethality to Ehrlich ascites tumor cells than that of the free drug and shows stronger inhibition ability on the DNA synthesis of the tumor cells. Thus the Ce(IV)-mitoxantrone complex may become a more potent antitumor drug than mitoxantrone. The different interaction model of mitoxantrone and its Ce(IV) complex with DNA were studied by the methods of spectroscopy, electrochemistry, and electrophoresis. Ce(IV) ions chelate with oxygens of the hydroxyl groups at the 1,4 position and the carbonyl function on C-9 and C-10, then intercalate into the base pairs of DNA together. The complexation of Ce(IV) gives rise to more compact binding of mitoxantrone with DNA, and leads to an additional change on the normal conformation and the double-helical structure of DNA; this may be related to the more stronger action of the complex on DNA synthesis and survival of cultured tumor cells.
ISSN:0162-0134
1873-3344
DOI:10.1016/S0162-0134(97)00030-5