Differential expression of mammalian TRP homologues across tissues and cell lines

Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the fu...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1997-10, Vol.239 (1), p.279-283
Main Authors: Garcia, R L, Schilling, W P
Format: Article
Language:English
Subjects:
Animals
Blotting, Southern
Calcium Channels - biosynthesis
Calcium Channels - genetics
Cattle
Humans
Jurkat Cells
Molecular Sequence Data
Rats
Rats, Sprague-Dawley
TRPC Cation Channels
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Summary:Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity of store-operated channels observed in these cells. However, there is little information as to which of these genes are co-expressed at the cellular level. We have examined the tissue specific expression of five mammalian trp genes and determined which are co-expressed in five different cell lines. The results show tissue- and cell-specific co-expression of multiple trp forms. This implies that the subunit composition of a particular CCE channel may vary depending on the cell type.
ISSN:0006-291X
DOI:10.1006/bbrc.1997.7458