Carcinosarcoma of the Uterus: A Clinicopathological Multicenter CTF Study

The purpose of this paper is to retrospectively analyze the clinical and pathological data of 118 cases of uterine carcinosarcoma. Prognostic factors and management were evaluated. χ2and log-rank tests were performed. Surgical stage at time of surgery was the most important prognostic factor (P<...

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Bibliographic Details
Published in:Gynecologic oncology 1997-10, Vol.67 (1), p.70-75
Main Authors: Sartori, Enrico, Bazzurini, Luca, Gadducci, Angiolo, Landoni, Fabio, Lissoni, Andrea, Maggino, Tiziano, Zola, Paolo, La Face, Beniamino
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinosarcoma - pathology
Carcinosarcoma - surgery
Carcinosarcoma - therapy
Chemotherapy, Adjuvant
Combined Modality Therapy
Disease-Free Survival
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Radiotherapy, Adjuvant
Retrospective Studies
Tumors
Uterine Neoplasms - pathology
Uterine Neoplasms - surgery
Uterine Neoplasms - therapy
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Summary:The purpose of this paper is to retrospectively analyze the clinical and pathological data of 118 cases of uterine carcinosarcoma. Prognostic factors and management were evaluated. χ2and log-rank tests were performed. Surgical stage at time of surgery was the most important prognostic factor (P< 0.0001); in stage I–II disease depth of myometrial invasion and lymphatic/vascular space involvement were significantly related to outcome, whereas other factors were not useful. In stage I–II patients postoperative radiation did not improve 5-year disease-free survival. Survival curves in patients with advanced disease treated with cisplatin-containing regimens or with doxorubicin (without cisplatin)-containing regimens were overlapping.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.1997.4827