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Penetration of erythrocyte membrane by peroxynitrite: participation of the anion exchange protein

Participation of the anion exchange protein (Band 3 protein) of the erythrocyte membrane in the transport of peroxynitrite into erythrocytes was shown by partial inhibition of hemoglobin oxidation by extracellular peroynitrite in cells treated with Band 3 inhibitors. These results demonstrate that p...

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Published in:Biochemistry and molecular biology international 1997-10, Vol.43 (2), p.319-325
Main Authors: Soszynski, Mirosław, Bartosz, Grzegorz
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Bartosz, Grzegorz
description Participation of the anion exchange protein (Band 3 protein) of the erythrocyte membrane in the transport of peroxynitrite into erythrocytes was shown by partial inhibition of hemoglobin oxidation by extracellular peroynitrite in cells treated with Band 3 inhibitors. These results demonstrate that permeation in the anionic form may be a minor pathway in the membrane transport of the peroxynitrite anion/peroxynitrous acid couple, especially in membranes reach in anion exchangers or channels.
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identifier ISSN: 1521-6543
ispartof Biochemistry and molecular biology international, 1997-10, Vol.43 (2), p.319-325
issn 1521-6543
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1521-6551
language eng
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source Wiley
subjects 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid - pharmacology
Adult
anion exchange
Anion Exchange Protein 1, Erythrocyte - antagonists & inhibitors
Anion Exchange Protein 1, Erythrocyte - metabolism
Anions
Band 3 protein
Biological Transport
erythrocyte
Erythrocyte Membrane - metabolism
Hemoglobins - metabolism
Humans
Hydrogen-Ion Concentration
Nitrates - metabolism
Oxidation-Reduction
peroxynitrite transport
title Penetration of erythrocyte membrane by peroxynitrite: participation of the anion exchange protein
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