ATTENUATION IN RAT BRAIN NITRIC OXIDE SYNTHASE ACTIVITY IN THE COARCTATION MODEL OF HYPERTENSION

The correlation of brain nitric oxide synthase (NOS) activity with renal hypertension has been investigated in rats. NOS activity was measured by oxyhaemoglobin and by conversion of radioactive arginine to citrulline. There was significant elevation of blood pressure (54% increase) along with left v...

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Bibliographic Details
Published in:Pharmacological research 1997-08, Vol.36 (2), p.109-114
Main Authors: HEGDE, L.G, SHUKLA, R, SRIMAL, R.C, DIKSHIT, M
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Animals
Antihypertensive Agents - therapeutic use
Aortic Coarctation
Blood Pressure - drug effects
Body Weight
Brain - drug effects
Brain - enzymology
brain nitric oxide synthase
Calcium Channel Blockers - therapeutic use
captopril
Captopril - therapeutic use
centhaquin
co-arctation induced hypertension
Heart - drug effects
Heart Rate - drug effects
Hypertension, Renovascular - drug therapy
Hypertension, Renovascular - enzymology
Hypertension, Renovascular - pathology
hypothalamus
Male
medulla
Myocardium - pathology
nifedipine
Nifedipine - therapeutic use
Nitric Oxide Synthase - metabolism
Organ Size
Piperazines - therapeutic use
Rats
Rats, Sprague-Dawley
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Summary:The correlation of brain nitric oxide synthase (NOS) activity with renal hypertension has been investigated in rats. NOS activity was measured by oxyhaemoglobin and by conversion of radioactive arginine to citrulline. There was significant elevation of blood pressure (54% increase) along with left ventricular hypertrophy (26% greater than the control) 8 weeks after coarctation. The brain NOS activity was also significantly reduced in coarctated animals (45% of the control value). Treatment with captopril (angiotensin converting enzyme inhibitor) or centhaquin (centrally acting antihypertensive agent) led to significant reduction of left ventricular hypertrophy and a marked recovery in the brain NOS activity (to 92% and 135% of the control, respectively). Nifedipine (a calcium channel blocker) also brought about normalization of blood pressure but the left ventricular hypertrophy was not prevented. The brain NOS activity in the nifedipine treated group also showed a significant trend of recovery (to 73% of the control NOS activity). The results suggested that there is an inverse correlation between brain NOS activity and blood pressure level.
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1997.0191