Mycoplasma genes: a case for reflective annotation

Although function can be assigned to genome sequence by homology at a macroscopic level, this can be misleading in the absence of data on enzyme activities. Together, such data can reveal whether open reading frames are expressed, identify multienzyme function and point to ‘orphan’ function. Because...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 1997-10, Vol.5 (10), p.413-419
Main Author: Dennis Pollack, J.
Format: Article
Language:English
Subjects:
Genes, Bacterial
Mycoplasma - genetics
Structure-Activity Relationship
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Summary:Although function can be assigned to genome sequence by homology at a macroscopic level, this can be misleading in the absence of data on enzyme activities. Together, such data can reveal whether open reading frames are expressed, identify multienzyme function and point to ‘orphan’ function. Because of their small size and small genomes, the genome sequences of some Mycoplasma spp. are very amenable to detailed analyses.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(97)01113-X