Detection of the Tumor-Associated Glycoprotein Antigen (TAG-72) in Premalignant Lesions of the Colon

We used monoclonal antibody B72.3 to study the expression of the colorectal carcinoma-associated antigen TAG-72 in premalignant colonic lesions with the immunoperoxidase technique. This antigen, which is rarely detectable in the normal colonic epithelium, was expressed in 13 of 19 adenomas with mode...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1989-12, Vol.81 (24), p.1913-1917
Main Authors: Wolf, Barbara C., D'Emilia, John C., Salem, Ronald R., DeCoste, Deborah, Sears, Henry F., Gottlieb, Leonard S., Steele, Glenn D.
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Antigens, Neoplasm - analysis
Colitis, Ulcerative - immunology
Colonic Polyps - immunology
Colorectal Neoplasms - immunology
Crohn Disease - immunology
Glycoproteins - analysis
Humans
Immunohistochemistry
Precancerous Conditions - immunology
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Summary:We used monoclonal antibody B72.3 to study the expression of the colorectal carcinoma-associated antigen TAG-72 in premalignant colonic lesions with the immunoperoxidase technique. This antigen, which is rarely detectable in the normal colonic epithelium, was expressed in 13 of 19 adenomas with moderate to severe dysplasia and nine of nine cases of inflammatory bowel disease. The antibody reacted with the normal-appearing mucosa adjacent to a carcinoma in 10 of 12 cases, although only eight of the tumors expressed the antigen. The expression of the TAG-72 antigen in the colonic epithelium may be an early marker of malignant transformation. (J Natl Cancer Inst 81: 1913–1917, 1989).
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/81.24.1913