Effects of allocryptopine, an alkaloid isolated from Glaucium arabicum on rat isolated ileum and urinary bladder

1. The alkaloid, allocryptopine, was isolated from the chloroform extract of Glaucium arabicum. 2. The effect of allocryptopine on urinary bladder and ileal smooth muscles was investigated in this study. 3. Allocryptopine, in concentrations from 1 x 10(-5) to 3 x 10(-3) M caused a concentration-depe...

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Bibliographic Details
Published in:General pharmacology 1997-10, Vol.29 (4), p.621-623
Main Authors: ABU-GHALYUN, Y, MASALMEH, A, AL-KHALIL, S
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
Animals
Berberine Alkaloids
Biological and medical sciences
Digestive system
Female
Ileum - drug effects
In Vitro Techniques
Male
Medical sciences
Methylene Blue - pharmacology
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Pharmacology. Drug treatments
Phentolamine - pharmacology
Phosphodiesterase Inhibitors - pharmacology
Rats
Receptors, Adrenergic, alpha - drug effects
Theophylline - pharmacology
Urinary Bladder - drug effects
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Summary:1. The alkaloid, allocryptopine, was isolated from the chloroform extract of Glaucium arabicum. 2. The effect of allocryptopine on urinary bladder and ileal smooth muscles was investigated in this study. 3. Allocryptopine, in concentrations from 1 x 10(-5) to 3 x 10(-3) M caused a concentration-dependent contraction of rat isolated urinary bladder and a concentration-dependent relaxation of rat ileal smooth muscles. 4. Theophylline (10(-5) M) shifted to the left the allocryptopine concentration-effect curve on ileum and increased the maximum inhibitory effect of allocryptopine. 5. Methylene blue (10(-3) M) had no significant effect on the concentration-effect curve of allocryptopine of the ileum. 6. Phentolamine (10(-6) M) shifted to the right the allocryptopine concentration-effect curve of urinary bladder. 7. These observations suggest that allocryptopine induces a relaxing effect on the ileum by inhibiting phosphodiesterase enzyme, and thus elevating cellular cAMP and its contractile effect on the urinary bladder by affecting alpha-adrenergic receptors in this tissue.
ISSN:0306-3623
1879-0011
DOI:10.1016/S0306-3623(96)00562-9