Effects of dietary fat saturation on eicosanoid production, platelet aggregation and blood pressure

• Published in: European journal of clinical investigation 1997-09, Vol.27 (9), p.780-787
• Main Authors: LAHOZ, C., ALONSO, R., ORDOVÁS, J. M., LÓPEZ-FARRÉ, A., DE OYA, M., MATA, P.
• Format: Article
• Language: English
• Subjects: 6-Ketoprostaglandin F1 alpha - analogs & derivatives; 6-Ketoprostaglandin F1 alpha - urine; Adolescent; Adult; Aged; Biological and medical sciences; Blood Pressure; Cholesterol - blood; Dietary Fats - administration & dosage; dietary study; eicosanoids; Eicosanoids - urine; endothelin; Endothelin-1 - blood; Energy Metabolism; fatty acids; Fatty Acids - administration & dosage; Fatty Acids, Unsaturated - administration & dosage; Female; Fundamental and applied biological sciences. Psychology; Hemodynamics. Rheology; Humans; Male; Middle Aged; Phospholipids - blood; Platelet Aggregation; Thromboxane B2 - analogs & derivatives; Thromboxane B2 - urine; Vertebrates: cardiovascular system
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1046/j.1365-2362.1997.1860735.x

The effects of dietary fat saturation on eicosanoid urinary excretion, platelet aggregation (PA) and blood pressure (BP) were studied in 42 healthy subjects. They consumed four consecutive diets differing in their fat saturation [saturated (SFA); monounsaturated (MUFA); polyunsaturated n‐6 (PUFA n‐6); and polyunsaturated n‐6/n‐3, (PUFA n‐3)]. Each diet period lasted 5 weeks. There were no differences in 24‐h 2,3‐dinor‐6‐keto‐prostaglandin F1α excretion among dietary periods. A significant effect was noted regarding the excretion of 11‐dehydro‐thromboxane B2 (P