Lactobacillus species as emerging pathogens in neutropenic patients

The intensive use of broad-spectrum antibiotics in the context of prolonged and severe neutropenia has contributed to the emergence of unusual pathogens. Four new cases of severe Lactobacillus infections-three of septicemia and one of pneumonia-are reported. They occurred in patients with acute leuk...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 1997-09, Vol.16 (9), p.681-684
Main Authors: FRUCHART, C, SALAH, A, GRAY, C, MARTIN, E, STAMATOULLAS, A, BONMARCHAND, G, LEMELAND, J. F, TILLY, H
Format: Article
Language:English
Subjects:
Adult
Antibiotics
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Ceftazidime - administration & dosage
Decontamination
Drug Therapy, Combination - therapeutic use
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - microbiology
Human bacterial diseases
Humans
Infectious diseases
Lactobacillus - drug effects
Lactobacillus - pathogenicity
Leukemia
Male
Medical sciences
Middle Aged
Neutropenia - drug therapy
Neutropenia - microbiology
Opportunistic Infections - drug therapy
Opportunistic Infections - microbiology
Pathogens
Penicillins - administration & dosage
Prophylaxis
Vancomycin - administration & dosage
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Summary:The intensive use of broad-spectrum antibiotics in the context of prolonged and severe neutropenia has contributed to the emergence of unusual pathogens. Four new cases of severe Lactobacillus infections-three of septicemia and one of pneumonia-are reported. They occurred in patients with acute leukemia who had chemotherapy-induced neutropenia. All patients were treated in the same intensive care unit and received the same antimicrobial prophylaxis which included a total bowel decontamination containing vancomycin. The four patients were treated with a combination of intravenous ceftazidime and vancomycin prior to the development of Lactobacillus infection. Improvement in the condition of all patients was obtained with a treatment including penicillin and concurrent recovery of granulopoiesis.
ISSN:0934-9723
1435-4373
DOI:10.1007/BF01708560