Loading…
Effects of midazolam, DMCM and lindane on potentiated startle in the rat
Forty-eight male Wistar rats were exposed to contingent light-shock combinations and 48 rats received light and shock stimuli in a random order. One day after fear conditioning the animals were tested for startle potentiation after injection of midazolam (0, 0.5, 1.0, 2.0 mg/kg, IP) or DMCM (methyl-...
Saved in:
| Published in: | Psychopharmacologia 1989-01, Vol.99 (3), p.362-365 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c311t-7f56fee884c01632acb1468e0fa2ff1df1537941a135aeca3e09dc2e3b21535a3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c311t-7f56fee884c01632acb1468e0fa2ff1df1537941a135aeca3e09dc2e3b21535a3 |
| container_end_page | 365 |
| container_issue | 3 |
| container_start_page | 362 |
| container_title | Psychopharmacologia |
| container_volume | 99 |
| creator | HIJZEN, T. H SLANGEN, J. L |
| description | Forty-eight male Wistar rats were exposed to contingent light-shock combinations and 48 rats received light and shock stimuli in a random order. One day after fear conditioning the animals were tested for startle potentiation after injection of midazolam (0, 0.5, 1.0, 2.0 mg/kg, IP) or DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate; 0, 0.1, 0.2, 0.4 mg/kg IP) or lindane (0, 7.5, 15.0, 30.0 mg/kg PO). Midazolam attenuated potentiated startle dose dependently and the inverse benzodiazepine agonist DMCM had the opposite effect. The effects of lindane on startle amplitudes were identical to those of DMCM, indicating that lindane has anxiogenic effects on behavior. It is suggested that the anxiogenic effects of lindane are mediated by an effect at the GABA-ionophore complex. |
| doi_str_mv | 10.1007/BF00445558 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79375010</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79375010</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-7f56fee884c01632acb1468e0fa2ff1df1537941a135aeca3e09dc2e3b21535a3</originalsourceid><addsrcrecordid>eNpFkLtOw0AQRVcIFEKgoUfaAlEgDLMv2ykhJAQpEQ3U1mQ9K4z8CLubAr4eI6wwzS3O0dXoMnYu4FYAZHcPCwCtjTH5ARsLrWQiIZOHbAygVKKEyY_ZSQgf0J_O9YiNpM4hFWbMlnPnyMbAO8ebqsTvrsbmhj-uZ2uObcnrqi2xJd61fNtFamOFkUoeIvpYE69aHt-Je4yn7MhhHehsyAl7W8xfZ8tk9fL0PLtfJVYJEZPMmdQR5bm2IFIl0W6ETnMCh9I5UTphVDbVAoUySBYVwbS0ktRG9sSgmrCrv96t7z53FGLRVMFSXfdfdrtQZFOVGRDQi9d_ovVdCJ5csfVVg_6rEFD8zlb8z9bLF0PrbtNQuVeHnXp-OXAMFmvnsbVV2GtppozUoH4ACAlyaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79375010</pqid></control><display><type>article</type><title>Effects of midazolam, DMCM and lindane on potentiated startle in the rat</title><source>Springer LINK Archives</source><creator>HIJZEN, T. H ; SLANGEN, J. L</creator><creatorcontrib>HIJZEN, T. H ; SLANGEN, J. L</creatorcontrib><description>Forty-eight male Wistar rats were exposed to contingent light-shock combinations and 48 rats received light and shock stimuli in a random order. One day after fear conditioning the animals were tested for startle potentiation after injection of midazolam (0, 0.5, 1.0, 2.0 mg/kg, IP) or DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate; 0, 0.1, 0.2, 0.4 mg/kg IP) or lindane (0, 7.5, 15.0, 30.0 mg/kg PO). Midazolam attenuated potentiated startle dose dependently and the inverse benzodiazepine agonist DMCM had the opposite effect. The effects of lindane on startle amplitudes were identical to those of DMCM, indicating that lindane has anxiogenic effects on behavior. It is suggested that the anxiogenic effects of lindane are mediated by an effect at the GABA-ionophore complex.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/BF00445558</identifier><identifier>PMID: 2480615</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acoustic Stimulation ; Animals ; Biological and medical sciences ; Carbolines - pharmacology ; Conditioning, Operant - drug effects ; Dose-Response Relationship, Drug ; Hexachlorocyclohexane - pharmacology ; Male ; Medical sciences ; Midazolam - pharmacology ; Miscellaneous ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments ; Photic Stimulation ; Rats ; Rats, Inbred Strains ; Reflex, Startle - drug effects</subject><ispartof>Psychopharmacologia, 1989-01, Vol.99 (3), p.362-365</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-7f56fee884c01632acb1468e0fa2ff1df1537941a135aeca3e09dc2e3b21535a3</citedby><cites>FETCH-LOGICAL-c311t-7f56fee884c01632acb1468e0fa2ff1df1537941a135aeca3e09dc2e3b21535a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6735240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2480615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIJZEN, T. H</creatorcontrib><creatorcontrib>SLANGEN, J. L</creatorcontrib><title>Effects of midazolam, DMCM and lindane on potentiated startle in the rat</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Forty-eight male Wistar rats were exposed to contingent light-shock combinations and 48 rats received light and shock stimuli in a random order. One day after fear conditioning the animals were tested for startle potentiation after injection of midazolam (0, 0.5, 1.0, 2.0 mg/kg, IP) or DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate; 0, 0.1, 0.2, 0.4 mg/kg IP) or lindane (0, 7.5, 15.0, 30.0 mg/kg PO). Midazolam attenuated potentiated startle dose dependently and the inverse benzodiazepine agonist DMCM had the opposite effect. The effects of lindane on startle amplitudes were identical to those of DMCM, indicating that lindane has anxiogenic effects on behavior. It is suggested that the anxiogenic effects of lindane are mediated by an effect at the GABA-ionophore complex.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbolines - pharmacology</subject><subject>Conditioning, Operant - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hexachlorocyclohexane - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Midazolam - pharmacology</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Photic Stimulation</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reflex, Startle - drug effects</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNpFkLtOw0AQRVcIFEKgoUfaAlEgDLMv2ykhJAQpEQ3U1mQ9K4z8CLubAr4eI6wwzS3O0dXoMnYu4FYAZHcPCwCtjTH5ARsLrWQiIZOHbAygVKKEyY_ZSQgf0J_O9YiNpM4hFWbMlnPnyMbAO8ebqsTvrsbmhj-uZ2uObcnrqi2xJd61fNtFamOFkUoeIvpYE69aHt-Je4yn7MhhHehsyAl7W8xfZ8tk9fL0PLtfJVYJEZPMmdQR5bm2IFIl0W6ETnMCh9I5UTphVDbVAoUySBYVwbS0ktRG9sSgmrCrv96t7z53FGLRVMFSXfdfdrtQZFOVGRDQi9d_ovVdCJ5csfVVg_6rEFD8zlb8z9bLF0PrbtNQuVeHnXp-OXAMFmvnsbVV2GtppozUoH4ACAlyaA</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>HIJZEN, T. H</creator><creator>SLANGEN, J. L</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890101</creationdate><title>Effects of midazolam, DMCM and lindane on potentiated startle in the rat</title><author>HIJZEN, T. H ; SLANGEN, J. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-7f56fee884c01632acb1468e0fa2ff1df1537941a135aeca3e09dc2e3b21535a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbolines - pharmacology</topic><topic>Conditioning, Operant - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hexachlorocyclohexane - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Midazolam - pharmacology</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Photic Stimulation</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reflex, Startle - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIJZEN, T. H</creatorcontrib><creatorcontrib>SLANGEN, J. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIJZEN, T. H</au><au>SLANGEN, J. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of midazolam, DMCM and lindane on potentiated startle in the rat</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>99</volume><issue>3</issue><spage>362</spage><epage>365</epage><pages>362-365</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Forty-eight male Wistar rats were exposed to contingent light-shock combinations and 48 rats received light and shock stimuli in a random order. One day after fear conditioning the animals were tested for startle potentiation after injection of midazolam (0, 0.5, 1.0, 2.0 mg/kg, IP) or DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate; 0, 0.1, 0.2, 0.4 mg/kg IP) or lindane (0, 7.5, 15.0, 30.0 mg/kg PO). Midazolam attenuated potentiated startle dose dependently and the inverse benzodiazepine agonist DMCM had the opposite effect. The effects of lindane on startle amplitudes were identical to those of DMCM, indicating that lindane has anxiogenic effects on behavior. It is suggested that the anxiogenic effects of lindane are mediated by an effect at the GABA-ionophore complex.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2480615</pmid><doi>10.1007/BF00445558</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacologia, 1989-01, Vol.99 (3), p.362-365 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79375010 |
| source | Springer LINK Archives |
| subjects | Acoustic Stimulation Animals Biological and medical sciences Carbolines - pharmacology Conditioning, Operant - drug effects Dose-Response Relationship, Drug Hexachlorocyclohexane - pharmacology Male Medical sciences Midazolam - pharmacology Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Photic Stimulation Rats Rats, Inbred Strains Reflex, Startle - drug effects |
| title | Effects of midazolam, DMCM and lindane on potentiated startle in the rat |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T15%3A04%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20midazolam,%20DMCM%20and%20lindane%20on%20potentiated%20startle%20in%20the%20rat&rft.jtitle=Psychopharmacologia&rft.au=HIJZEN,%20T.%20H&rft.date=1989-01-01&rft.volume=99&rft.issue=3&rft.spage=362&rft.epage=365&rft.pages=362-365&rft.issn=0033-3158&rft.eissn=1432-2072&rft.coden=PSYPAG&rft_id=info:doi/10.1007/BF00445558&rft_dat=%3Cproquest_cross%3E79375010%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c311t-7f56fee884c01632acb1468e0fa2ff1df1537941a135aeca3e09dc2e3b21535a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=79375010&rft_id=info:pmid/2480615&rfr_iscdi=true |