Correlation between antiretroviral resistance mutations, biological parameters, and clinical evolution in zidovudine-treated patients infected with human immunodeficiency virus type 1

To evaluate the correlation between zidovudine (ZDV) resistance mutations of human immunodeficiency virus type 1 (HIV-1), biological parameters, and clinical evolution, 111 HIV-1-infected patients treated with ZDV were studied. Specific mutations at codons 70, 215, and 41 in the HIV-1 reverse transc...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 1997-09, Vol.16 (9), p.660-668
Main Authors: LERICHE-GUERIN, K, TRABAUD, M. A, COTTE, L, BISSUEL, F, DERUELLE, E, ROUGIER, P, TREPO, C
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
AIDS/HIV
Analysis of Variance
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Biological and medical sciences
CD4 Lymphocyte Count
Disease Progression
Drug Resistance - genetics
Evolution
Female
HIV
HIV Core Protein p24 - analysis
HIV Core Protein p24 - immunology
HIV Infections - drug therapy
HIV Infections - genetics
HIV Infections - virology
HIV Reverse Transcriptase - genetics
HIV Reverse Transcriptase - immunology
HIV-1 - drug effects
HIV-1 - genetics
Human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Male
Medical sciences
Multivariate analysis
Mutation
Polymerase Chain Reaction
RNA, Viral - analysis
Zidovudine - therapeutic use
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Summary:To evaluate the correlation between zidovudine (ZDV) resistance mutations of human immunodeficiency virus type 1 (HIV-1), biological parameters, and clinical evolution, 111 HIV-1-infected patients treated with ZDV were studied. Specific mutations at codons 70, 215, and 41 in the HIV-1 reverse transcriptase coding region conferring resistance to ZDV were detected using a selective polymerase chain reaction. The appearance of ZDV resistance mutations was significantly correlated with baseline clinical stage, CD4+ cell count, and viral load, but not with duration of ZDV therapy or p24 antigen level. In univariate analysis, results showed a prognostic role of mutations at codons 215 and 41 for clinical progression to the acquired immune deficiency syndrome (AIDS) or death. In multivariate analysis after controlling for viral load, CD4+ cell count, and clinical stage, the presence of the mutation at codon 215 (but not at codon 41) remained an independent predictor of subsequent clinical evolution.
ISSN:0934-9723
1435-4373
DOI:10.1007/BF01708556