Protective effect of chronic garlic intake on elastic properties of aorta in the elderly

Epidemiological studies have suggested that garlic may have protective effects against cardiovascular diseases. We undertook this cross-sectional observational study to test the hypothesis that regular garlic intake would delay the stiffening of the aorta relating to aging. We studied healthy adults...

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Published in:Circulation (New York, N.Y.) N.Y.), 1997-10, Vol.96 (8), p.2649-2655
Main Authors: BREITHAUPT-GRÖGLER, K, LING, M, BOUDOULAS, H, BELZ, G. G
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - physiology
Aorta - drug effects
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Cross-Sectional Studies
Elasticity
Female
Garlic
Heart Rate
Humans
Lipids - blood
Male
Medical sciences
Middle Aged
Plants, Medicinal
Protective Agents - pharmacology
Vascular Resistance
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Summary:Epidemiological studies have suggested that garlic may have protective effects against cardiovascular diseases. We undertook this cross-sectional observational study to test the hypothesis that regular garlic intake would delay the stiffening of the aorta relating to aging. We studied healthy adults (n=101; age, 50 to 80 years) who were taking > or = 300 mg/d of standardized garlic powder for > or = 2 years and 101 age- and sex-matched control subjects. Pulse wave velocity (PWV) and pressure-standardized elastic vascular resistance (EVR) were used to measure the elastic properties of the aorta. Blood pressures, heart rate, and plasma lipid levels were similar in the two groups. PWV (8.3+/-1.46 versus 9.8+/-2.45 m/s; P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.96.8.2649