Diagnostic and Prognostic Value of Dipyridamole and Dobutamine Stress Echocardiography in Patients With Q-Wave Acute Myocardial Infarction

The aim of this study was to compare dipyridamole and dobutamine stress echocardiography, performed early in patients with acute myocardial infarction (AMI) to evaluate residual ischemia, viability, and prognosis. Fifty patients (mean age 55 ± 9 years, 47 men, 3 women) with AMI, all treated with thr...

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Bibliographic Details
Published in:The American journal of cardiology 1997-10, Vol.80 (7), p.847-851
Main Authors: Minardi, Giovanni, Di Segni, Marcello, Manzara, Carla C., Pulignano, Giovanni, Chiantera, Angelo, De Santis, Francesco, Armiento, Gianluca, Vajola, Fabio S., Giovannini, Ezio
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Dipyridamole
Dobutamine
Echocardiography - methods
Exercise Test
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - diagnostic imaging
Prognosis
Sensitivity and Specificity
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Summary:The aim of this study was to compare dipyridamole and dobutamine stress echocardiography, performed early in patients with acute myocardial infarction (AMI) to evaluate residual ischemia, viability, and prognosis. Fifty patients (mean age 55 ± 9 years, 47 men, 3 women) with AMI, all treated with thrombolytic therapy, underwent standard dipyridamole and dobutamine tests, within the fifth day of the event. Wall motion score index and the 16 segments model were used to evaluate contractility. Forty-seven patients underwent coronary angiography within the tenth day of the event. The mean follow-up was 24 ± 12 months. No side effects occurred during both tests. Both dipyridamole and dobutamine tests were positive for ischemia, in 32 and 33 of 47 patients, respectively (sensitivity 73% and 75%; specificity 67% and 67%); these tests induced an improvement of contractility in 23 and 38 of 139 abnormal segments at baseline, respectively (sensitivity 52% and 86%; specificity 100% and 100%). Cardiac events occurred in 26 of 50 patients, 22 with a positive dipyridamole test and 21 with positive dobutamine test. Thus, both tests were feasible, safe, and useful to evaluate residual ischemia, viability, and prognosis. No significant differences were found in sensitivity and specificity between tests.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00534-1