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Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia
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| Published in: | Journal of medicinal chemistry 1997-09, Vol.40 (20), p.3141-3143 |
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Language: | English |
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| container_end_page | 3143 |
| container_issue | 20 |
| container_start_page | 3141 |
| container_title | Journal of medicinal chemistry |
| container_volume | 40 |
| creator | Meyer, M D Altenbach, R J Basha, F Z Carroll, W A Drizin, I Elmore, S W Ehrlich, P P Lebold, S A Tietje, K Sippy, K B Wendt, M D Plata, D J Plagge, F Buckner, S A Brune, M E Hancock, A A Kerwin, Jr, J F |
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Altenbach, R J ; Basha, F Z ; Carroll, W A ; Drizin, I ; Elmore, S W ; Ehrlich, P P ; Lebold, S A ; Tietje, K ; Sippy, K B ; Wendt, M D ; Plata, D J ; Plagge, F ; Buckner, S A ; Brune, M E ; Hancock, A A ; Kerwin, Jr, J F</creator><creatorcontrib>Meyer, M D ; Altenbach, R J ; Basha, F Z ; Carroll, W A ; Drizin, I ; Elmore, S W ; Ehrlich, P P ; Lebold, S A ; Tietje, K ; Sippy, K B ; Wendt, M D ; Plata, D J ; Plagge, F ; Buckner, S A ; Brune, M E ; Hancock, A A ; Kerwin, Jr, J F</creatorcontrib><identifier>ISSN: 0022-2623</identifier><identifier>PMID: 9379432</identifier><language>eng</language><publisher>United States</publisher><subject>Adrenergic alpha-1 Receptor Antagonists ; Adrenergic alpha-Antagonists - chemical synthesis ; Adrenergic alpha-Antagonists - therapeutic use ; Animals ; Dogs ; Humans ; Indoles - chemical synthesis ; Indoles - therapeutic use ; Isoindoles ; Male ; Models, Chemical ; Prazosin - analogs & derivatives ; Prazosin - therapeutic use ; Prostatic Hyperplasia - drug therapy ; 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Altenbach, R J ; Basha, F Z ; Carroll, W A ; Drizin, I ; Elmore, S W ; Ehrlich, P P ; Lebold, S A ; Tietje, K ; Sippy, K B ; Wendt, M D ; Plata, D J ; Plagge, F ; Buckner, S A ; Brune, M E ; Hancock, A A ; Kerwin, Jr, J F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p532-f34e8a58d1b720bd8c0d6876a5256db289d6a7abca92a6cbdb1a882cd0fd52c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenergic alpha-1 Receptor Antagonists</topic><topic>Adrenergic alpha-Antagonists - chemical synthesis</topic><topic>Adrenergic alpha-Antagonists - therapeutic use</topic><topic>Animals</topic><topic>Dogs</topic><topic>Humans</topic><topic>Indoles - chemical synthesis</topic><topic>Indoles - therapeutic use</topic><topic>Isoindoles</topic><topic>Male</topic><topic>Models, Chemical</topic><topic>Prazosin - analogs & derivatives</topic><topic>Prazosin - therapeutic use</topic><topic>Prostatic Hyperplasia - drug therapy</topic><topic>Pyrimidinones - chemical synthesis</topic><topic>Pyrimidinones - therapeutic use</topic><topic>Rats</topic><topic>Receptors, Adrenergic, alpha-1</topic><topic>Sulfonamides - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyer, M D</creatorcontrib><creatorcontrib>Altenbach, R J</creatorcontrib><creatorcontrib>Basha, F Z</creatorcontrib><creatorcontrib>Carroll, W A</creatorcontrib><creatorcontrib>Drizin, I</creatorcontrib><creatorcontrib>Elmore, S W</creatorcontrib><creatorcontrib>Ehrlich, P P</creatorcontrib><creatorcontrib>Lebold, S A</creatorcontrib><creatorcontrib>Tietje, K</creatorcontrib><creatorcontrib>Sippy, K B</creatorcontrib><creatorcontrib>Wendt, M D</creatorcontrib><creatorcontrib>Plata, D J</creatorcontrib><creatorcontrib>Plagge, F</creatorcontrib><creatorcontrib>Buckner, S A</creatorcontrib><creatorcontrib>Brune, M E</creatorcontrib><creatorcontrib>Hancock, A A</creatorcontrib><creatorcontrib>Kerwin, Jr, J F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyer, M D</au><au>Altenbach, R J</au><au>Basha, F Z</au><au>Carroll, W A</au><au>Drizin, I</au><au>Elmore, S W</au><au>Ehrlich, P P</au><au>Lebold, S A</au><au>Tietje, K</au><au>Sippy, K B</au><au>Wendt, M D</au><au>Plata, D J</au><au>Plagge, F</au><au>Buckner, S A</au><au>Brune, M E</au><au>Hancock, A A</au><au>Kerwin, Jr, J F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J Med Chem</addtitle><date>1997-09-26</date><risdate>1997</risdate><volume>40</volume><issue>20</issue><spage>3141</spage><epage>3143</epage><pages>3141-3143</pages><issn>0022-2623</issn><cop>United States</cop><pmid>9379432</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1997-09, Vol.40 (20), p.3141-3143 |
| issn | 0022-2623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79384448 |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists - chemical synthesis Adrenergic alpha-Antagonists - therapeutic use Animals Dogs Humans Indoles - chemical synthesis Indoles - therapeutic use Isoindoles Male Models, Chemical Prazosin - analogs & derivatives Prazosin - therapeutic use Prostatic Hyperplasia - drug therapy Pyrimidinones - chemical synthesis Pyrimidinones - therapeutic use Rats Receptors, Adrenergic, alpha-1 Sulfonamides - therapeutic use |
| title | Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia |
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