Immunohistochemical demonstration of bcl-2 protein in ameloblastoma

The bcl‐2 gene is known through its product, bcl‐2 protein, which prevents apoptosis. and also by its expression in development, especially in sites characterized by epithelial‐mesenchymal interactions. In the developing tooth germ, bcl‐2‐protein is expressed in the epithelial component. In this stu...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 1997-09, Vol.26 (8), p.345-348
Main Authors: Mitsuyasu, Takeshi, Harada, Hidemitsu, Higuchi, Yoshinori, Kimura, Ken-ichi, Nakamura, Norifumi, Katsuki, Takeshi, Kubola, Eiro, Toyoshima, Kuniaki, Ohishi, Masamichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
ameloblastoma
Ameloblastoma - pathology
Antibodies, Monoclonal
Apoptosis - genetics
bcl-2 protein
Biological and medical sciences
Cell Division
Cell Nucleus - ultrastructure
Cytoplasm - ultrastructure
Dentistry
Ent. Stomatology
Epithelium - growth & development
Epithelium - metabolism
Female
Gene Expression Regulation, Developmental
Genes, bcl-2 - genetics
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Jaw Neoplasms - pathology
Male
Medical sciences
Mesoderm - metabolism
Mesoderm - physiology
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Proto-Oncogene Proteins c-bcl-2 - analysis
Proto-Oncogene Proteins c-bcl-2 - genetics
Stem Cells - metabolism
Stem Cells - pathology
Tooth Germ - growth & development
Tooth Germ - metabolism
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Summary:The bcl‐2 gene is known through its product, bcl‐2 protein, which prevents apoptosis. and also by its expression in development, especially in sites characterized by epithelial‐mesenchymal interactions. In the developing tooth germ, bcl‐2‐protein is expressed in the epithelial component. In this study, we examined the expression of bcl‐2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti‐human bcl‐2 oncoprotein. In all 25 cases, bcl‐2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum‐like cells and squamoid cells) were negative. The bcl‐2 protein is therefore thought to play a role in maintaining the stem‐cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.
ISSN:0904-2512
1600-0714
DOI:10.1111/j.1600-0714.1997.tb00228.x