Zollinger-Ellison syndrome in a patient with normal screening gastrin level

A 59-year-old female presented with multifocal peptic ulcer disease and diarrhea. A fasting serum gastrin level obtained while the patient was receiving no antacid therapy was normal. A secretin stimulation test was positive. A small gastrinoma was found in the anterior duodenal wall at exploratory...

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Bibliographic Details
Published in:Digestive diseases and sciences 1989-12, Vol.34 (12), p.1929-1932
Main Authors: YANDA, R. J, OSTROFF, J. W, ASHBAUGH, C. D, GUIS, M. S, GOLDBERG, H. I
Format: Article
Language:English
Subjects:
Biological and medical sciences
Duodenal Neoplasms - blood
Duodenal Neoplasms - diagnosis
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Gastrinoma - blood
Gastrinoma - diagnosis
Gastrins - blood
Humans
Medical sciences
Middle Aged
Tumors. Hypoglycemia
Zollinger-Ellison Syndrome - blood
Zollinger-Ellison Syndrome - diagnosis
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Summary:A 59-year-old female presented with multifocal peptic ulcer disease and diarrhea. A fasting serum gastrin level obtained while the patient was receiving no antacid therapy was normal. A secretin stimulation test was positive. A small gastrinoma was found in the anterior duodenal wall at exploratory laparotomy. Normal fasting gastrin levels do occur in patients with overt Zollinger-Ellison syndrome and should not deter further investigation if clinical suspicion of this syndrome is high.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01536714