Role of Brain Angiotensin in Thirst and Sodium Appetite of Rats

• Published in: Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1997, Vol.18 (7), p.977-984
• Main Authors: Weisinger, R.S, Blair-West, J.R, Burns, P, Denton, D.A, Tarjan, E
• Format: Article
• Language: English
• Subjects: Angiotensin II - physiology; Angiotensin II receptor antagonists; Angiotensin Receptor Antagonists; Animals; Appetite - drug effects; Appetite - physiology; Brain - physiology; Drinking - drug effects; Drinking - physiology; Eating - drug effects; Eating - physiology; Furosemide - pharmacology; Imidazoles - administration & dosage; Imidazoles - pharmacology; Injections, Intraventricular; Losartan - administration & dosage; Losartan - pharmacology; Male; Pyridines - administration & dosage; Pyridines - pharmacology; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - physiology; Sodium - metabolism; Sodium appetite; Sodium, Dietary - administration & dosage; Thirst; Thirst - drug effects; Thirst - physiology
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/S0196-9781(97)00077-6

WEISINGER, R. S., J. R. BLAIR-WEST, P. BURNS, D. A. DENTON AND E. TARJAN. Role of brain angiotensin in thirst and sodium appetite of rats. PEPTIDES 18(7) 977–984, 1997.—The role of brain angiotensin II (ANG II) in water, Na and food intake of rats was studied. Intracerebroventricular (ICV) infusion (100 μg/h) of the non-peptide ANG II receptor antagonist losartan (type 1), but not PD123319 (type 2), completely blocked water intake caused by ICV infusion of ANG II at 50 ng/h. Following food deprivation, food intake was reduced by PD123319 and associated water intake was decreased by losartan or PD123319. Neither water intake after water deprivation nor Na intake after Na depletion was altered by losartan or PD123319. In conclusion, evidence was consistent with a role for brain ANG II in both food and water intake after food deprivation but not in thirst subsequent to water deprivation or Na intake after Na depletion alone.