Temporal Relationship between Human Immunodeficiency Virus Type 1 RNA Levels in Serum and Cellular Infectious Load in Peripheral Blood

Cross-sectional analysis of 252 paired serum and peripheral blood mononuclear cell (PBMC) samples derived from 54 human immunodeficiency virus type 1 (HIV-1)-infected persons revealed a correlation between HIV-1 RNA load in serumand infectious load in peripheral CD4 T cells after 18 months of follow...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-11, Vol.176 (5), p.1383-1387
Main Authors: Blaak, Hetty, Wolf, Frank de, van 't Wout, Angelique B., Pakker, Nadine G., Bakker, Margreet, Goudsmit, Jaap, Schuitemaker, Hanneke
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - blood
Acquired Immunodeficiency Syndrome - virology
AIDS
AIDS/HIV
Antivirals
Biological and medical sciences
Blood
Blood plasma
CD4 Lymphocyte Count
Concise Communications
Cross-Sectional Studies
Disease progression
HIV 1
HIV-1 - isolation & purification
Human viral diseases
Humans
Infections
Infectious diseases
Medical sciences
RNA
RNA, Viral - blood
T lymphocytes
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viremia - virology
Viruses
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Summary:Cross-sectional analysis of 252 paired serum and peripheral blood mononuclear cell (PBMC) samples derived from 54 human immunodeficiency virus type 1 (HIV-1)-infected persons revealed a correlation between HIV-1 RNA load in serumand infectious load in peripheral CD4 T cells after 18 months of follow-up and before an AIDS diagnosis (Pearson's correlation coefficient [rp] = .71, P < .001) and during antiviral treatment (rp = .78, P < .001). To gain insight into the temporal relationship between both measures of virus load, longitudinally obtained samples from 23 persons with various clinical courses (slow or rapid disease progression, long-term survival) and 22 persons undergoing antiviral therapy (zidovudine or didanosine, or both, or ritonavir) were analyzed. In general, the kinetics of changes in both measures of virus load were similar in the natural course of infection (78% of study participants) and during treatment (82% of participants). These findings suggest that PBMC and serum represent closely related, if not the same, viral compartments.
ISSN:0022-1899
1537-6613
DOI:10.1086/517327