Levels of infectivity in the blood throughout the incubation period of hamsters peripherally injected with scrapie

Viremia is found in intraperitoneally scrapie-injected hamsters. The absence of a viremic peak before the beginning of scrapie replication in the brain suggests either that the spread of the agent to the brain is not via the blood or that early after infection, circulating monocytes carry the agent...

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Bibliographic Details
Published in:Archives of virology 1989-01, Vol.108 (1/2), p.145-149
Main Authors: Casaccia, P, Ladogana, A, Xi, Y.G, Pocchiari, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - microbiology
Cricetinae
Fundamental and applied biological sciences. Psychology
hamsters
incubation
Microbiology
pathogenicity
Prions - growth & development
Prions - pathogenicity
replication
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
scrapie
Scrapie - microbiology
Spleen - microbiology
Viremia - microbiology
Virology
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Description
Summary:Viremia is found in intraperitoneally scrapie-injected hamsters. The absence of a viremic peak before the beginning of scrapie replication in the brain suggests either that the spread of the agent to the brain is not via the blood or that early after infection, circulating monocytes carry the agent to the brain where it remains silent until the neural cells start replicating it.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01313752